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FLASH GENE
Symbol CCAR1 contributors: mct - updated : 26-12-2018
HGNC name cell division cycle and apoptosis regulator 1
HGNC id 24236
Location 10q21.3      Physical location : 70.480.970 - 70.551.307
Synonym name
  • death inducer with SAP domain
  • Cell Cycle and Apoptosis Regulatory Protein 1
  • Synonym symbol(s) CARP1, CARP-1, FLJ10590, FLJ10839
    DNA
    TYPE functioning gene
    STRUCTURE 71.23 kb     25 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text
  • SRSF5 promotes the alternative splicing of CCAR1 to produce CCAR1S proteins, which promote tumor growth by enhancing glucose consumption and acetyl-CoA production (PMID: 29942010)
  • identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    25 - 4769 - 1150 - 2014 24245781
    24 - 4730 - 1135 - 2014 24245781
    24 - 4724 - 1135 - 2014 24245781
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivemouthtongue   
    Reproductivemale systemprostate   
    Respiratoryrespiratory tractlarynx  highly
    Urinarybladder    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    text
  • NEUROG3 and CCAR1 are co-localized in the nucleus
  • basic FUNCTION
  • key mediator of signaling by CD437 or adriamycin allows for delineation of pathways that, in turn, may prove beneficial for design and targeting of novel antitumor agents
  • apoptosis inducer, that regulates apoptosis signaling by diverse agents, including adriamycin and growth factors
  • promotes apoptosis by activating MAPK14 and caspase-9, and is involved in apoptosis signaling by epidermal growth factor receptor
  • regulates expression of key proliferation-inducing genes
  • also functions as a TP53 coactivator, suggesting a broader role in transcriptional regulation
  • function as a transcriptional coactivator for nuclear receptors, also interacts with beta-catenin and enhances the ability of beta-catenin to activate expression of transiently transfected reporter genes
  • perinuclear phospho-protein, regulating signaling by adriamycin, steroids, or growth factors (
  • important co-activator for estrogen-induced gene expression and estrogen-dependent growth of breast cancer cells
  • can serve as a co-activator for different classes of transcription factors to maintain the balance of proliferation, apoptosis, and differentiation
  • potential role in PTH signaling and bone anabolic action
  • positively regulates adipocyte differentiation through the glucocorticoid signaling pathway
  • CCAR2 and CCAR1 are largely disordered proteins that have evolved from one common ancestor
  • plays a dynamic role in regulation of cell growth and apoptosis by serving as a cofactor of steroid/thyroid nuclear receptors, CTNNB1, and TP53 in a variety of cell types including different cancer cells
  • CCAR1 contributes to carcinogenesis in gastric cancer and is required for the survival of gastric cancer cells
  • CCAR1 is a novel transcriptional cofactor for NR1I3
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • novel component of Wnt/beta-catenin signaling that plays an important role in transcriptional regulation by beta-catenin
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • 14-3-3 protein as well as causes reduced expression of cell cycle regulatory genes including c-Myc and cyclin B1
  • microtubule dependent association of AKAP9 and CCAR1 with RNA stress granules
  • binds with signal transducer TAZ and over-expression of TAZ inhibits apoptosis by CCAR1
  • transcriptional coactivator for nuclear receptors, also interacts with NEUROG3
  • NDN exerts its pro-survival activity by counteracting the action of the pro-apoptotic protein Cell Cycle Apoptosis Regulatory Protein (CCAR1/CARP1)
  • can act as an enhancer-dependent coactivator of NR1I3 1)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may serve as a diagnostic marker in gastric cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    may represent a novel target for therapeutic intervention in cancers involving aberrantly activated Wnt/beta-catenin signaling
    cancer  
    SRSF5-CCAR1 axis may be valuable targets for cancer therapeutics
    cancerdigestivestomach
    potential therapeutic target in gastric cancer
    ANIMAL & CELL MODELS