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FLASH GENE
Symbol CBX8 contributors: mct - updated : 22-03-2008
HGNC name chromobox homolog 8 (Pc class homolog, Drosophila)
HGNC id 15962
Location 17q25.3      Physical location : 77.768.177 - 77.770.915
Synonym name polycomb 3
Synonym symbol(s) HPC3, RC1, PC3
DNA
TYPE functioning gene
STRUCTURE 2.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
TIMP2 17q25..3 tissue inhibitor of metalloproteinase 2 LGALS3BP 17q25.2-q25.3 lectin, galactoside-binding, soluble, 3 binding protein SHAPY 17q25.3 Ca2+-dependent endoplasmic reticulum nucleoside diphosphatase C1QTNF1 17q25.2 C1q and tumor necrosis factor related protein 1 LOC388422 17 LOC388422 FLJ21865 17q25.3 endo-beta-N-acetylglucosaminidase LOC339162 17q25.3 similar to ataxin 2-binding protein 1 isoform 2; hexaribonucleotide binding protein 1 LOC388423 17 LOC388423 LOC201109 17q25.3 hypothetical LOC201109 LOC339221 17q25.3 Alkaline sphingomyelinase MGC10561 17q25.3 hypothetical protein MGC10561 CBX8 12p13.32 chromobox homolog 8 (Pc class homolog, Drosophila) CBX4 17q25.3 chromobox homolog 4 (Pc class homolog, Drosophila) MGC25062 LOC388424 17 similar to hypothetical protein FLJ20753 FLJ20753 17q25.3 hypothetical protein FLJ20753 GAA 17q25.2-q25.3 glucosidase, alpha; acid (Pompe disease, glycogen storage disease type II) DDX48 17q25.3 DEAD (Asp-Glu-Ala-Asp) box polypeptide 48 LOC388425 17 hypothetical gene supported by BC035394 CARD14 17q25 caspase recruitment domain family, member 14 SGSH 17q25.3 N-sulfoglucosamine sulfohydrolase (sulfamidase) SLC26A11 17q25 solute carrier family 26, member 11 KIAA1618 17q25.3 KIAA1618 protein KIAA1554 17q25.3 KIAA1554 protein FLJ35220 17q25.3 hypothetical protein FLJ35220 LOC388426 17 hypothetical gene supported by AK090819 NPTX1 17q25.2 neuronal pentraxin I LOC201259 17q25.3 similar to 60S ribosomal protein L32 raptor 17q25.3 raptor
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1542 - 389 - Dietrich (2007)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus    
Reproductivefemale systemuteruscervix  
Respiratoryrespiratory tractlarynx   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal chromo domain (chromatin organization modifier), conserved and chromobox regions that were dispensable for chromatin association
  • an alternating charge cluster and a C terminal C box domain
  • HOMOLOGY
    interspecies homolog to Drosophila PC
    Homologene
    FAMILY
    CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in the repression of transcriptional activity
  • regulates proliferation of diploid human and mouse fibroblasts through direct binding to the INK4A-ARF locus
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text transcriptional silencer
    PATHWAY
    metabolism
    signaling
    a component part of one of the PRC1 complexes (polycomb repressive complexes 1)
    INTERACTION
    DNA
    RNA
    small molecule
    protein RING1
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with AF9 in t(9;11)(p22;q23) in acute leukemias
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS