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FLASH GENE
Symbol CBX7 contributors: mct - updated : 09-02-2011
HGNC name chromobox homolog 7
HGNC id 1557
Location 22q13.1      Physical location : 39.526.789 - 39.548.538
Synonym name
  • Drosophila polycomb-like (PcG) chromobox homolog 7, mouse ortholog
  • chromobox protein homolog 7
  • DNA
    TYPE functioning gene
    STRUCTURE 21.76 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D22S272 - PDGFB - CBX7 - D22S423 - D22S1171 - D22S274 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 3964 - 251 - 2007 17374722
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousnervecranial nerve  highly
    Visualeye   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticprogenitor cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a chromatin organization modifier (chromo) domain conserved
  • chromobox regions dispensable for chromatin association
  • HOMOLOGY
    interspecies homolog to Drosophila polycomb-like (PcG) chromobox 7 and HP1b
    ortholog to murine Cbx7
    Homologene
    FAMILY
  • polycomb group proteins family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in the compaction of chromatin
  • controls the growth of normal and tumor-derived prostate cells by repressing the CDKN2A
  • chromobox protein causally linked to cancer development and may help explain the low frequency of CDKN2A mutations observed in human follicular lymphoma
  • acts as an oncogene in the carcinogenesis and progression of gastric cancer
  • may regulate tumorigenesis, cell migration and cancer metastasis partially via CDKN2A regulatory pathway
  • within the polycomb repressive complex 1 binds to CDKN2BAS and both CBX7 and CDKN2BAS are found at elevated levels in prostate cancer tissues
  • necessary for recruitment of RNF2 to chromatin, whereas RYBP enhances the PRC1 enzymatic activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the Polycomb repressive complex 1 (PRC1) that extends the lifespan of cultured epithelial cells
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • correlation between CBX7 and E-cadherin (CDH1) expression in thyroid carcinomas
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate tumor cells
    tumoral     --over  
    in follicular lymphoma
    tumoral     --low  
    drastically down-regulated in six thyroid carcinoma cell lines
    tumoral     --low  
    loss of CBX7 expression correlates with a highly malignant phenotype in thyroid cancer patients
    tumoral     --over  
    in gastric cancer cell lines and gastric tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    target for control of follicular lymphoma in the clinic
    ANIMAL & CELL MODELS