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FLASH GENE
Symbol CBX3 contributors: mct/npt/pgu - updated : 11-10-2017
HGNC name chromobox homolog 3 (HP1 gamma homolog, Drosophila)
HGNC id 1553
Location 7p15.2      Physical location : 26.241.098 - 26.252.974
Synonym name
  • heterochromatin-like protein 1
  • modifier 2 protein
  • heterochromatin protein HP1 gamma
  • Synonym symbol(s) HECH, HP1-GAMMA, HP1HS-GAMMA, HP1G
    DNA
    TYPE functioning gene
    STRUCTURE 11.88 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure housekeeping gene
    MAPPING cloned Y linked N status provisional
    Physical map
    ACTL6 7q22 actin-like 6 GNB2 7q21.1-q22.2 guanine nucleotide binding protein (G protein), beta polypeptide 2 PERQ1 7q22 PERQ amino acid rich, with GYF domain 1 RPP20 7q22 POP7 (processing of precursor, S. cerevisiae) homolog EPO 7q21.3-q22.1 erythropoietin NFE2L3 7p15-p14 nuclear factor (erythroid-derived 2)-like 3 ZAN 7q22 zonadhesin HNRPA2B1 7p15.3 heterogeneous nuclear ribonucleoprotein A2/B1 CBX3 7p21.1 chromobox homolog 3 (HP1 gamma homolog, Drosophila) EPHB4 7q32-q36 EphB4 LOC392761 7 LOC392761 SLC12A9 7q22 solute carrier family 12 (potassium/chloride transporters), member 9 TRIP6 7q22 thyroid hormone receptor interactor 6 SNX10 7p21.1 sorting nexin 10 ARS2 7q21 arsenate resistance protein ARS2 LOC392963 7 similar to RIKEN cDNA 2700038N03 ACHE 7q22.1 acetylcholinesterase (YT blood group) LOC392762 7 similar to intestinal mucin 3 NFE2L3 7p15-p14 nuclear factor (erythroid-derived 2)-like 3 KIAA0087 7p15.2 nuclear factor (erythroid-derived 2)-like 3 HNRPA2B1 7p15.3 heterogeneous nuclear ribonucleoprotein A2/B1 CBX3 7p21.1 chromobox homolog 3 (HP1 gamma homolog, Drosophila) SNX10 7p21.1 sorting nexin 10 SCAP2 7p21-p15 src family associated phosphoprotein 2
    RNA
    TRANSCRIPTS type messenger
    text two transcript variants encoding the same protein but differing in the 5' UTR
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1837 20.8 183 - 2008 18618731
  • this variant (1) contains an alternate 5' exon but encodes the same protein as transcript variant 2
  • 6 - 1851 20.8 183 - 2008 18618731
    this variant (2) contains an alternate 5' exon but encodes the same protein as transcript variant 1
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
    Cardiovascularheart   highly
    Digestiveliver   highly
    Endocrinepancreas    
    Nervousbrain   highly
    Reproductivemale systemprostate  highly
    Respiratorylung   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a chromatin organization modifier (chromo) domain conserved and chromobox regions were dispensable for chromatin association
  • one chromo shadow domain
  • HOMOLOGY
    interspecies homolog to murine Cbx3
    ortholog to Drosophila HP1b
    homolog to C.elegans K0G5.2A
    intraspecies homolog to CBX1
    Homologene
    FAMILY
  • polycomb group proteins family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,heterochromosome
    intracellular,nuclear envelope
    basic FUNCTION
  • implicated in heterochromatin association with inner nuclear membrane
  • functioning in gene silencing, transcriptional regulation and chromatin remodeling
  • is released from chromatin during the M phase of the cell cycle, upon H3 serine 10 phosphorylation
  • housekeeping genes possessing a dominant ubiquitously-acting chromatin opening element (UCOE) capability
  • involved in transient repression of inducible promoters
  • recruited to heterochromatin in association with SUV420H2, and stably maintained at its heterochromatin sites in an CBX -independent fashion
  • having a non-redundant function during spermatogenesis that cannot be compensated for by the other two CBX1 and CBX5
  • novel role during the cellular response to oxidative stress
  • CBX3 disulfide dimerization plays a pivotal role in cell survival under oxidative conditions
  • potentially acts as a rapid redox sensor, and it may connect the intracellular redox state with transcriptional regulation under various physiological conditions
  • specific role for CBX1, CBX3, CBX5 in regulating SUV39H1 function under stress via a feedback mechanism that likely regulates heterochromatin formation
  • has an important role in carcinogenesis by regulating several mechanisms, such as heterochromatin formation, gene silencing, DNA replication and repair
  • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text transcription repressor
    PATHWAY
    metabolism
    signaling
    a component
  • conserved components of eukaryotic constitutive heterochromatin
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • binding to lamin B receptor (LBR)
  • binding to CHAF1A
  • binding to TAFII 130
  • CBX3 negatively regulated FBP1 expression
  • CBX3 serves as a positive regulator of aerobic glycolysis via suppressing of the FBP1 in pancreatic cancer cells
  • cell & other
    REGULATION
    Other phosphorylated by PIM-1 kinase
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerendocrinepancreas
    disrupting the CBX3-FBP1 signaling axis would be effective to treat pancreatic cancer and prevent aerobic glycolysis
    ANIMAL & CELL MODELS