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FLASH GENE
Symbol CBX1 contributors: mct/npt/pgu - updated : 11-10-2017
HGNC name chromobox homolog 1 (HP1 beta homolog Drosophila)
HGNC id 1551
Location 17q21.32      Physical location : 46.147.414 - 46.178.883
Synonym name
  • heterochromatin protein-1
  • modifier 1 protein
  • heterochromatin protein p25 beta
  • Synonym symbol(s) CBX, M31, MOD1, HP1-beta, p25beta, HP1Hsbeta
    DNA
    TYPE functioning gene
    STRUCTURE 31.47 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    NPEPPS 17q21.2-q21.32 aminopeptidase puromycin sensitive KPNB1 17q21.32 karyopherin (importin) beta 1 ProSAPiP2 17q21.32 ProSAPiP2 protein TBX21 17q21.3 T-box 21 OSBPL7 17q21.2 oxysterol binding protein-like 7 MRPL10 17q21.32 mitochondrial ribosomal protein L10 MGC16309 17q21.32 hypothetical gene MGC16309 Ses2 17q21.32 secernin 2 SP6 17q21.3-q22 Sp6 transcription factor LOC388398 17 LOC388398 SP2 17q21.3-q22 Sp2 transcription factor PNPO 17q21.32 pyridoxine-5'-phosphate oxidase MGC11242 17q21.32 hypothetical protein MGC11242 CDK5RAP3 17q21.2 CDK5 regulatory subunit associated protein 3 COPZ2 17q21.3 coatomer protein complex, subunit zeta 2 NFE2L1 17q21.3 nuclear factor (erythroid-derived 2)-like 1 CBX1 17q21.32 chromobox homolog 1 (HP1 beta homolog Drosophila ) SNX11 17q21.2 sorting nexin 11 SCAP1 17q21.32 src family associated phosphoprotein 1 HOXB1 17q21.3 homeo box B1 HOXB2 17q21.3 homeo box B2 HOXB3 17q21.3 homeo box B3 HOXB4 17q21.3 homeo box B4 HOXB5 17q21.3 homeo box B5 HOXB6 17q21.3 homeo box B6
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 splicing 2443 - 185 - 2002 11959914
    encoding the same protein than variant 2
    5 splicing 2253 21.3 185 - 2002 11959914
  • differing in the 5' UTR compared to variant 1
  • encoding the same protein than variant 1
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
     vesselsaorta   
    Digestiveesophagus   moderately
    Endocrineparathyroid   predominantly
    Hearing/Equilibriumear   highly
    Lymphoid/Immunethymus    
    Nervousbrain    
    Reproductivefemale systemuteruscervix moderately
     female systemovary  moderately
    Respiratorylung    
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  moderately
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal
    Text embryonic tissues, highly in umbilical cord
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a single N-terminal chromodomain (chromatin modifier domain) which can bind to histone proteins via methylated lysine residues
  • a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins
  • mono polymer homomer , dimer
    HOMOLOGY
    intraspecies homolog to CBX5
    homolog to HSM1
    Homologene
    FAMILY
  • family of heterochromatic adaptor molecules
  • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,heterochromosome
    intracellular,nucleus,chromatin/chromosome,centromere
    text
  • associated with the centromere
  • pronucleus
  • basic FUNCTION
  • mediating gene silencing
  • contributing to the association of the heterochromatin with the inner nuclear membrane
  • is released from chromatin during the M phase of the cell cycle, upon H3 serine 10 phosphorylation
  • recognizing histone H3 tails methylated at 'Lys-9', leading to epigenetic repression
  • involved in transient repression of inducible promoters
  • present on the promoter together with the non-processive HNRNPA2B1 and functions as a negative regulator
  • novel role during the cellular response to oxidative stress
  • potentially acts as a rapid redox sensor, and it may connect the intracellular redox state with transcriptional regulation under various physiological conditions
  • WDR76 co-localizes to puncta with the heterochromatin proteins CBX1 and CBX5, which are also recruited to DNA damage but much less intensely than WDR76
  • specific role for CBX1, CBX3, CBX5 in regulating SUV39H1 function under stress via a feedback mechanism that likely regulates heterochromatin formation
  • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the heterochromatin complex with NuMa proteins, dynein and dynactin, a complex that is necessary for mitosis
  • conserved components of eukaryotic constitutive heterochromatin
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • binding to lamin B receptor (LBR)
  • binding to CHAF1A
  • binding to methylated histone H3
  • interacting directly with EMSY, TIF1/TIF1A and TRIM28/TIF1B PXVXL motif via the chromoshadow domain
  • interacting with SUV39H1 and SETDB1, SUV420H1 and SUV420H2
  • CBX1 binds to sites of histone H3 lysine 9 (H3K9) methylation, and is primarily responsible for gene silencing and the formation of heterochromatin
  • interaction with SUV39H1 (SUV39H1-independent association of CBX1 with fibrillarin-positive nucleolar regions)
  • the presence of CBX1 in nucleoli is likely connected with transcription of ribosomal genes and with the role of fibrillarin in nucleolar processes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS