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FLASH GENE
Symbol CBX1 contributors: mct/npt/pgu - updated : 11-10-2017
HGNC name chromobox homolog 1 (HP1 beta homolog Drosophila)
HGNC id 1551
Location 17q21.32      Physical location : 46.147.414 - 46.178.883
Synonym name
  • heterochromatin protein-1
  • modifier 1 protein
  • heterochromatin protein p25 beta
  • Synonym symbol(s) CBX, M31, MOD1, HP1-beta, p25beta, HP1Hsbeta
    DNA
    TYPE functioning gene
    STRUCTURE 31.47 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 splicing 2443 - 185 - 2002 11959914
    encoding the same protein than variant 2
    5 splicing 2253 21.3 185 - 2002 11959914
  • differing in the 5' UTR compared to variant 1
  • encoding the same protein than variant 1
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
     vesselsaorta   
    Digestiveesophagus   moderately
    Endocrineparathyroid   predominantly
    Hearing/Equilibriumear   highly
    Lymphoid/Immunethymus    
    Nervousbrain    
    Reproductivefemale systemuteruscervix moderately
     female systemovary  moderately
    Respiratorylung    
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  moderately
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal
    Text embryonic tissues, highly in umbilical cord
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a single N-terminal chromodomain (chromatin modifier domain) which can bind to histone proteins via methylated lysine residues
  • a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins
  • mono polymer homomer , dimer
    HOMOLOGY
    intraspecies homolog to CBX5
    homolog to HSM1
    Homologene
    FAMILY
  • family of heterochromatic adaptor molecules
  • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,heterochromosome
    intracellular,nucleus,chromatin/chromosome,centromere
    text
  • associated with the centromere
  • pronucleus
  • basic FUNCTION
  • mediating gene silencing
  • contributing to the association of the heterochromatin with the inner nuclear membrane
  • is released from chromatin during the M phase of the cell cycle, upon H3 serine 10 phosphorylation
  • recognizing histone H3 tails methylated at 'Lys-9', leading to epigenetic repression
  • involved in transient repression of inducible promoters
  • present on the promoter together with the non-processive HNRNPA2B1 and functions as a negative regulator
  • novel role during the cellular response to oxidative stress
  • potentially acts as a rapid redox sensor, and it may connect the intracellular redox state with transcriptional regulation under various physiological conditions
  • WDR76 co-localizes to puncta with the heterochromatin proteins CBX1 and CBX5, which are also recruited to DNA damage but much less intensely than WDR76
  • specific role for CBX1, CBX3, CBX5 in regulating SUV39H1 function under stress via a feedback mechanism that likely regulates heterochromatin formation
  • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the heterochromatin complex with NuMa proteins, dynein and dynactin, a complex that is necessary for mitosis
  • conserved components of eukaryotic constitutive heterochromatin
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • binding to lamin B receptor (LBR)
  • binding to CHAF1A
  • binding to methylated histone H3
  • interacting directly with EMSY, TIF1/TIF1A and TRIM28/TIF1B PXVXL motif via the chromoshadow domain
  • interacting with SUV39H1 and SETDB1, SUV420H1 and SUV420H2
  • CBX1 binds to sites of histone H3 lysine 9 (H3K9) methylation, and is primarily responsible for gene silencing and the formation of heterochromatin
  • interaction with SUV39H1 (SUV39H1-independent association of CBX1 with fibrillarin-positive nucleolar regions)
  • the presence of CBX1 in nucleoli is likely connected with transcription of ribosomal genes and with the role of fibrillarin in nucleolar processes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS