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FLASH GENE
Symbol CBR4 contributors: mct-np - updated : 03/10/2008
HGNC name carbonyl reductase 4
HGNC id 25891
Location 4q32.3      Physical location : 169.908.743 - 169.931.468
Synonym name
  • cDNA FLJ77331, highly similar to Homo sapiens carbonic reductase 4
  • short chain dehydrogenase/reductase family 45C, member 1
  • Synonym symbol(s) FLJ14431, DKFZp762K109, SDR45C1
    EC.number 1.1.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 22.68 kb     5 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 3474 25 237 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver     Homo sapiens
    Urinarykidney     Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • non-cleavable mitochondrial targeting signal
  • mono polymer tetramer
    HOMOLOGY
    interspecies homolog to rattus Cbr4 (85.5 pc)
    homolog to murine Cbr4 (86.8 pc)
    Homologene
    FAMILY
  • short-chain dehydrogenases/reductases (SDR) family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • acting as an oxydoreductase
  • mitochondrial NADPH-dependent quinone reductase
  • may be involved in the induction of apoptosis by cytotoxic 9,10-phenanthrenequinone
  • its localization in the mitochondria that participate in key steps of the apoptotic signal cascade induced by oxidative stress
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • NADP
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS