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FLASH GENE
Symbol CBLN2 contributors: mct - updated : 21-09-2011
HGNC name cerebellin 2 precursor
HGNC id 1544
Location 18q22.3      Physical location : 70.203.914 - 70.211.723
DNA
TYPE functioning gene
SPECIAL FEATURE head to head
STRUCTURE 7.81 kb     5 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 2910 - 224 - 1994 7877445
EXPRESSION
Rna function
  • CBLN1, CBLN2 and CBLN4 mRNAs are expressed in distinct brain regions, but these regions are partly overlapping
  • mRNAs of CBLN(1 to 4) expressed in the human adrenal gland (
  • Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain     Homo sapiens
     brainforebrain  highly Homo sapiens
     gangliasensory gangliadorsal root   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text in the developing spinal cord
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    a C1Q domain
    mono polymer heteromer
    HOMOLOGY
    intraspecies homolog to CBLN1
    Homologene
    FAMILY
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • CBLN1, CBLN2 and CBLN4 may serve as transneuronal regulators of synaptic functions in various brain regions
  • may generally serve as a new class of transneuronal regulators of synapse development and synaptic plasticity in various brain regions
  • can play a role in the formation and maintenance of synapses, and it may somehow mediate bi-directional communication between discrete populations of neurons and their appropriate neuronal targets
  • with CBLN1 and CBLN4, exert synaptogenic activities in cortical neurons by differentially interacting with NRXN variants containing S4
  • CBLN1, and CBLN2 induced preferentially inhibitory rather than excitatory presynaptic differentiation of cortical neurons when compared with NLGN1
  • unique and general roles of CBLN1, CBLN2, CBLN4 in mediating the formation and maintenance of synapses not only in the cerebellum but also in various other brain regions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NRXNs may mediate synapse formation in the forebrain by interacting with CBLN1, CBLN2 and CBLN4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS