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FLASH GENE
Symbol CBLN2 contributors: mct - updated : 21-09-2011
HGNC name cerebellin 2 precursor
HGNC id 1544
Location 18q22.3      Physical location : 70.203.914 - 70.211.723
DNA
TYPE functioning gene
SPECIAL FEATURE head to head
STRUCTURE 7.81 kb     5 Exon(s)
MAPPING cloned Y linked N status provisional
Physical map
CDH19 18q22-q23 cadherin 19, type 2 NCAG1 18q22.1 NCAG1 LOC390862 18 similar to SECIS-binding protein 2 LOC342800 18q22.1 similar to ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b, isoform 1 LOC390863 18 similar to aldo-keto reductase family 1, member B10; aldose reductase-like 1; aldo-keto reductase family 1, member B11 (aldose reductase-like); aldose reductase-like peptide; aldose reductase-related protein; small intestine reducta FLJ20793 18q22 FLJ20793 protein FLJ23594 18q22.1 hypothetical protein FLJ23594 MGC20785 18q22.2 hypothetical protein MGC20785 CD226 18q22.3 CD226 antigen RTTN 18q22.1 rotatin SOCS4 18q22.2 suppressor of cytokine signaling 4 LOC339306 18q22.2 hypothetical LOC339306 LOC342808 18q22.2 similar to 40S ribosomal protein S2 CBLN2 18q23 cerebellin 2 precursor NETO1 18q22.2 neuropilin (NRP) and tolloid (TLL)-like 1 LOC388481 18 LOC388481 FBXO15 18q22.3 F-box only protein 15 HSPC154 18q22.3 HSPC154 protein CYB5 18q23 cytochrome b-5 FAUP1 18 FBR-MuSV-associated ubiquitously expressed (fox derived) pseudogene 1 LOC125704 18q22.3 similar to hypothetical protein B230399E16 CN2 18q22.3 cytosolic nonspecific dipeptidase (EC 3.4.13.18) CN1 18q22.3 carnosinase 1 ZNF407 18q23 zinc finger protein 407 MGC45594 18q22.3 hypothetical protein MGC45594 SDCCAG33 18q22.3 serologically defined colon cancer antigen 33 LOC388482 18 LOC388482 LOC284275 18q23 hypothetical LOC284275 KIAA0222 18q23 hypothetical LOC284275 ZNF236 18q22-q23 zinc finger protein 236 MBP 18q23 myelin basic protein LOC388483 18 LOC388483 GALR1 18q23 galanin receptor 1 LOC390864 18 similar to amino acid feature: Rod protein domain, aa 266 .. 468; amino acid feature: globular protein domain, aa 32 .. 265 LOC125595 18q23 hypothetical LOC125595 LOC390865 18 similar to hypothetical protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 2910 - 224 - 1994 7877445
EXPRESSION
Rna function
  • CBLN1, CBLN2 and CBLN4 mRNAs are expressed in distinct brain regions, but these regions are partly overlapping
  • mRNAs of CBLN(1 to 4) expressed in the human adrenal gland (
  • Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain     Homo sapiens
     brainforebrain  highly Homo sapiens
     gangliasensory gangliadorsal root   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text in the developing spinal cord
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    a C1Q domain
    mono polymer heteromer
    HOMOLOGY
    intraspecies homolog to CBLN1
    Homologene
    FAMILY
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • CBLN1, CBLN2 and CBLN4 may serve as transneuronal regulators of synaptic functions in various brain regions
  • may generally serve as a new class of transneuronal regulators of synapse development and synaptic plasticity in various brain regions
  • can play a role in the formation and maintenance of synapses, and it may somehow mediate bi-directional communication between discrete populations of neurons and their appropriate neuronal targets
  • with CBLN1 and CBLN4, exert synaptogenic activities in cortical neurons by differentially interacting with NRXN variants containing S4
  • CBLN1, and CBLN2 induced preferentially inhibitory rather than excitatory presynaptic differentiation of cortical neurons when compared with NLGN1
  • unique and general roles of CBLN1, CBLN2, CBLN4 in mediating the formation and maintenance of synapses not only in the cerebellum but also in various other brain regions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NRXNs may mediate synapse formation in the forebrain by interacting with CBLN1, CBLN2 and CBLN4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS