Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

CBLN2

contributors: mct - updated : 22-03-2022

HGNC name	cerebellin 2 precursor
HGNC id	1544

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	18q22.3      Physical location : 70.203.914 - 70.211.723

DNA

TYPE	functioning gene
SPECIAL FEATURE	head to head
STRUCTURE	104.77 kb     5 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_182511 5 - 2747 NP_872317 - 224 - 1994 7877445

EXPRESSION

Rna function	CBLN1, CBLN2 and CBLN4 mRNAs are expressed in distinct brain regions, but these regions are partly overlapping
	mRNAs of CBLN(1 to 4) expressed in the human adrenal gland (
Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Homo sapiens   brain forebrain     highly Homo sapiens   ganglia sensory ganglia dorsal root     Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	in the developing spinal cord

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two N-linked glycosylation sites, one at the N-terminus is in a region implicated in NRXN binding and the second is in the C1q domain, a region involved in GRID2 binding
	a C1Q domain

mono polymer

heteromer

HOMOLOGY

intraspecies

homolog to CBLN1

Homologene

FAMILY

CATEGORY

immunity/defense

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane

basic FUNCTION	CBLN1, CBLN2 and CBLN4 may serve as transneuronal regulators of synaptic functions in various brain regions
	may generally serve as a new class of transneuronal regulators of synapse development and synaptic plasticity in various brain regions
	can play a role in the formation and maintenance of synapses, and it may somehow mediate bi-directional communication between discrete populations of neurons and their appropriate neuronal targets
	with CBLN1 and CBLN4, exert synaptogenic activities in cortical neurons by differentially interacting with NRXN variants containing S4
	CBLN1, and CBLN2 induced preferentially inhibitory rather than excitatory presynaptic differentiation of cortical neurons when compared with NLGN1
	unique and general roles of CBLN1, CBLN2, CBLN4 in mediating the formation and maintenance of synapses not only in the cerebellum but also in various other brain regions
	CBLN2 can exhibit functional redundancy with CBLN1 in cerebellum but it does not have the same properties as CBLN1 in thalamic neurons 8)
	synaptic organizer molecule that bind to presynaptic neurexins and postsynaptic receptors
	not essential for survival and do not contribute to initial synapse formation, but perform multiple functions throughout the brain

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

NRXNs may mediate synapse formation in the forebrain by interacting with CBLN1, CBLN2 and CBLN4

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS