| basic FUNCTION
| stimulating norepinephrine release via the adenylate cyclase/pka- dependent signaling pathway |
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indirectly enhancing adrenocortical secretion through a paracrine mechanism involving medullary catecholamine release |
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CBLN1, CBLN2 and CBLN4 may serve as transneuronal regulators of synaptic functions in various brain regions  |
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can play two unique roles at excitatory synapses formed between cerebellar granule cells and Purkinje cells: the formation and stabilization of synaptic contact, and the control of functional synaptic plasticity by regulating the postsynaptic endocytosis pathway |
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unique synapse organizer that is required not only for the normal development of PF-Purkinje cell synapses but also for their maintenance in the mature cerebellum |
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released from cerebellar granule cells and plays a crucial role in forming and maintaining excitatory synapses between parallel fibers (PFs; axons of granule cells) and Purkinje cells not only during development but also in the adult cerebellum |
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determines the dendritic structure of striatal medium spiny neurons, with effects distinct from those seen in the cerebellum |
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play an important role in the formation and maintenance of parallel fiber-Purkinje cell synapses |
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with CBLN2 and CBLN4, exert synaptogenic activities in cortical neurons by differentially interacting with NRXN variants containing S4 |
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CBLN1, and CBLN2 induced preferentially inhibitory rather than excitatory presynaptic differentiation of cortical neurons when compared with NLGN1 |
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CBLN2 can exhibit functional redundancy with CBLN1 in cerebellum but it does not have the same properties as CBLN1 in thalamic neurons 8) |
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plays an essential role to establish parallel fiber-Purkinje cell synapses and to regulate balance between excitatory and inhibitory input on Purkinje cells |
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predominantly expressed in cerebellar granule cells and plays a crucial role in the formation and function of parallel fiber-Purkinje cell synapses |
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CBLN1 signaling likely regulates motor and non-motor functions in multiple brain regions |
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CBLN1 and C1QL1 proteins regulate the formation and maintenance of parallel fiber-Purkinje cell and climbing fiber-Purkinje cell synapses, respectively, in the cerebellum |
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co-release of CBLN1 and CTSB from lysosomes serves as a new mechanism of activity-dependent coordinated synapse modification |
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CBLN1 and postsynaptic receptor GLUD2 mediate synaptogenesis between granule cells and Purkinje cells in the molecular layer of the cerebellar cortex |
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