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FLASH GENE
Symbol CBLC contributors: mct - updated : 24-02-2015
HGNC name Cas-Br-M (murine) ecotropic retroviral transforming sequence c
HGNC id 15961
Location 19q13.32      Physical location : 45.281.125 - 45.303.902
Synonym name
  • CBL family-adaptor protein 3
  • RING finger protein 57
  • signal transduction protein CBL-C
  • SH3-binding protein CBL-C
  • Synonym symbol(s) CBL3, CBL-SL, RNF57
    DNA
    TYPE functioning gene
    STRUCTURE 22.78 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    ZNF233 19q13.32 zinc finger protein 233 ZNF235 19q13.3 zinc finger protein 235 MRPS15P2 19q13.32 zinc finger protein 235 ZNF228 19q13.2 zinc finger protein 228 LOC388549 19 LOC388549 ZNF285  zinc finger protein 285 ZNF229 19q13.2 zinc finger protein 229 LOC147711 19q13.32 similar to zinc finger protein 285 ZNF180 19q13.1-q13.3 zinc finger protein 180 (HHZ168) UNQ9366 19q13.32 GPAD9366 LOC388550 19 similar to CEACAM5 protein LOC390941 19 LOC390941 LOC147710 19q13.32 hypothetical LOC147710 PVR 19q13.2 poliovirus receptor CEAL1 19q13.32 carcinoembryonic antigen-like 1 LOC388551 19 similar to carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) BCL3 19q13.2 B-cell CLL/lymphoma 3 CBLC 19q13.2-q13.3 Cas-Br-M (murine) ecotropic retroviral transforming sequence c LU 19q12-q13 Lutheran blood group (Auberger b antigen included) PVRL2 19q13.2-q13.4 poliovirus receptor-related 2 (herpesvirus entry mediator B) TOMM40 19q13 translocase of outer mitochondrial membrane 40 homolog (yeast) APOE 19q13.2 apolipoprotein E APOC1 19q13.2 apolipoprotein C-I APOC4 19q13.2 apolipoprotein C-IV APOC2 19q13.2 apolipoprotein C-II CLPTM1 19q13.2 cleft lip and palate associated transmembrane protein 1 RELB 19q13.32 v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (avian) SFRS16 19q13.3 splicing factor, arginine/serine-rich 16 (suppressor-of-white-apricot homolog, Drosophila) ZNF342 19q13.32 zinc finger protein 342 GEMIN7 19q13.32 gem (nuclear organelle) associated protein 7 EIF5AP3 19q13.2 eukaryotic translation initiation factor 5A pseudogene 3 LOC284352 19q13.32 hypothetical protein LOC284352 FLJ33600 19q13.32 FLJ33600 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 1591 52 474 - 1999 10362357
  • long form
  • 10 splicing 1453 - 428 pancreatic adenocarcinoma 1999 10362357
    short form
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     intestinesmall intestine   
     mouth    
    Respiratorylung    
     respiratory tractlarynx   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cell lineage
    cell lines pancreatic adenocarcinoma
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • conserved N-terminal tyrosine kinase binding (TKB) domain showed restricted structural flexibility upon phosphopeptide binding, and mutation in CBLC TKB augmenting this flexibility enhanced its binding to target phosphoproteins
  • a phosphotyrosine binding domain
  • a catalytic RING finger domain
  • C-terminal proline-rich domain that mediates interactions with SRC homology 3 (SH3) containing proteins
  • HOMOLOGY
    interspecies homolog to murine Cblc
    Homologene
    FAMILY
  • CBL family-adaptor protein 3
  • RING finger ubiquitin ligases family
  • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • regulating intracellular signaling mediated by various tyrosine kinase
  • down-regulates receptor tyrosine kinases by conjugating ubiquitin to them, leading to receptor internalization and degradation
  • CD2AP and CBLC, constitute a checkpoint that controls the extent of RET downregulation and, thereby, the sensitivity of neurons to glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Src is a preferential target of CBLC for degradation
  • RTK negative regulatory gene
  • interacts with unphosphorylated RET and dissociates from RET after RET activation
  • TGFB1I1 is a CBLC interacting protein (binding leads to an increase in the ubiquitin ligase activity of CBLC once CBLC has been activated by SRC phosphorylation or through an activating phosphomimetic mutation)
  • PDLIM7 is a CBLC interacting protein, and binding of PDLIM7 to RET prevents CBLC recruitment to RET
  • binds wild-type and MEN2A isoforms of the receptor tyrosine kinase, RET, and enhances ubiquitination and degradation of activated RET
  • cell & other
  • EGF receptor and Fyn tyrosine kinase binding
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS