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FLASH GENE
Symbol CATSPER3 contributors: - updated : 21-09-2007
HGNC name cation channel, sperm associated 3
HGNC id 20819
Location 5q31.2      Physical location : 134.303.595 - 134.347.397
Synonym name putative ion channel CatSper3, calcium channel repeat containing 1, one-repeat calcium channel-like gene
Synonym symbol(s) CACRC
DNA
TYPE functioning gene
SPECIAL FEATURE opposite orientation
text in head-to-tail orientation with DCOHM gene
STRUCTURE 43.00 kb     8 Exon(s)
MAPPING cloned Y linked N status provisional
Physical map
HTGN29 5q31.1 HTGN29 protein VDAC1 5q31 voltage-dependent anion channel 1 TCF7 5q31.1 transcription factor 7 (T-cell specific, HMG-box) SKP1A 7q11.2 S-phase kinase-associated protein 1A (p19A) PPP2CA 5q23-q31 protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform CDKL3 5q31 cyclin-dependent kinase-like 3 UBE2B 5q31 ubiquitin-conjugating enzyme E2B (RAD6 homolog) MGC13017 5q31.2 similar to RIKEN cDNA A430101B06 gene LOC391833 5 similar to 40S ribosomal protein S10 PHF15 5q31.2 PHD finger protein 15 SARA2 5q31.1 SAR1a gene homolog 2 (S. cerevisiae) SEC24A 5 SEC24 related gene family, member A (S. cerevisiae) CAMLG 5q23 calcium modulating ligand DDX46 5q31.2 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 FLJ37562 5q31.2 hypothetical protein FLJ37562 FLJ22625 5q31.2 hypothetical protein FLJ22625 DCOHM 5q31.2 hypothetical protein FLJ22625 CATSPER3 5q31.2 cation channel, sperm associated 3 PITX1 5q31 paired-like homeodomain transcription factor 1 LOC389328 5 LOC389328 LOC389329 5 LOC389329 H2AFY 5q31.3-q32 H2A histone family, member Y DCNP1 5q31.2 dendritic cell nuclear protein 1 LOC345607 5q31.2 similar to FLJ00292 protein NEUROG1 5q23-q31 neurogenin 1 CXCL14 5q31 chemokine (C-X-C motif) ligand 14 LOC389330 5 LOC389330 LOC389331 5 LOC389331 LOC153328 5q31.2 similar to CG4995 gene product
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 intestinelarge intestinecolon  
 pharynx   highly
Reproductivemale systemtestis  predominantly
 male systemprostate  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatid
Reproductivespermatozoa
Skin/Tegumentmelanocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • coiled-coil protein-protein interaction domains in the C-terminal tail
  • a single-ion transport domain with six transmembrane spanning regions, in which the fourth transmembrane region resembles a voltage sensor and a pore-forming region lies between transmembrane regions 5 and 6
    • mono polymer heteromer , tetramer
    HOMOLOGY
    intraspecies homolog to CATSPER1, CATSPER2
    Homologene
    FAMILY Catsper family
    CATEGORY receptor membrane ligand ion channel
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • voltage-gated Ca2+ channel
  • forms a functional heterotetrameric channel in sperm (in association with Casper 1, 2 and 3)
  • cation-channel protein having roles in acrosome reaction and male fertility
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    Ca2+ binding
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS