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FLASH GENE

Symbol

CASP7

contributors: mct - updated : 21-01-2011

HGNC name	caspase 7, apoptosis-related cysteine peptidase
HGNC id	1508

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	10q25.3      Physical location : 115.438.934 - 115.490.662
Synonym name	caspase 7, apoptosis-related cysteine protease
	apoptotic protease Mch-3
	ICE-like apoptotic protease 3
	Lice2 alpha/beta/gamma
	caspase 7 isoform delta
Synonym symbol(s)	MCH3, CMH-1, ICE-LAP3
EC.number	3.4.22.60

DNA

TYPE	functioning gene
STRUCTURE	51.73 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - [D10S168 - D10S554 - D10S1269 ] - qter
Text	[CASP7 ]

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_033339 8 splicing 2679 NP_203125 34 303 - 1995 8521391 protein isoform Alpha a 8 exons variant containing exon 3b (shorter than 3a) containing exon 7a (longer than 7b) lacking exons 1 & 8 also called MCH3-Alpha or Lice2-Gamma NM_033340 8 splicing 2433 NP_203126 27.9 253 - 1995 8521391 protein isoform Beta a 8 exons variant containing exon 7b (shorter than 7a) lacking exons 2 & 3 not proteolytically active also called MCH3-Beta NM_001227 7 splicing 2605 NP_001218 34 303 - 1995 8521391 protein isoform Alpha precursor a 7 exons variant containing exon 7a (longer than 7b) lacking exons 1, 3 & 8 also called Lice2-Alpha NM_033338 8 splicing 2712 NP_203124 37 336 widely, not in brain 1995 8521391 protein isoform Delta or Alpha' a 8 exons variant containing exons 3a & 7a (respectively longer than 3b & 7b) lacking exons 1 & 8 encoding for the longest product also called Lice2-Beta

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel       highly Digestive mouth       moderately Lymphoid/Immune spleen         Nervous nerve       moderately Reproductive female system uterus     highly Respiratory respiratory tract trachea     moderately Urinary bladder       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Connective bone

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal (Fas-associating protein with DEATH domain) FADD-like death effector domain
	a conserved QACXG pentapeptide active site motif

mono polymer

heteromer , dimer

isoforms

Precursor

precursor producing two subunits, large and small that dimerize

HOMOLOGY

interspecies	homolog to rattus Casp7 (85,15 pc)
	homolog to murine Casp7 (82,18 pc)

Homologene

FAMILY

peptidase C14 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,cytosolic,microsome
	intracellular,nucleus,nucleoplasm
text	stored in the mitochondrial intermembrane space and released into cytosol after appropriate apoptotic stimuli

basic FUNCTION	cysteine containing aspartate-specific protease
	involved in the execution phase of apoptosis
	CASP3 was found to be generally more promiscuous than CASP7 and appears to be the major executioner caspase during the demolition phase of apoptosis
	executioner caspase that plays a key role in apoptosis, cancer, and a number of neurodegenerative diseases
	calpain-activated form of caspase-7 has unique enzymatic activity, localization, and binding affinity when compared with the caspase-activated form
	considered to be redundant with CASP3 because these related cysteine proteases share an optimal peptide recognition sequence and have several endogenous protein substrates in common
	CASP3 and CASP7 exhibit differences in protease activity, specific homodimer-forming activity, and three-dimensional structural features, all of which are closely interrelated

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	cleaving and activating sterol regulatory element binding proteins
	cleaving poly (adp-ribose) polymerase (PARP)
	calpain during B cell clonal deletion by apoptosis
	binding to and ubiquitinated by BIRC2
	CAPN1-activated form of CASP7 has unique enzymatic activity, localization, and binding affinity when compared with the caspase-activated form
	presynaptic protein ATCAY is a substrate of CASP3 and CASP7
	after activation by CASP9, CASP3 inhibits ROS production and is required for efficient execution of apoptosis, while effector CASP7 is required for apoptotic cell detachment

cell & other

REGULATION

induced by

PHB on the CASP7 promoter mediated through p53 binding sites

inhibited by

BIRC2, BIRC3, BIRC4 (XIAP)

Other	regulated by its terminal peptide
	positively controlled by SREBF1 and SREBF2

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   LOH     in several solid cancers

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	interfering with CASP7 activation may hold therapeutic value for the treatment of cancer
	System Type Disorder Pubmed cancer

ANIMAL & CELL MODELS