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FLASH GENE
Symbol CASC3 contributors: np/mct - updated : 02-03-2011
HGNC name cancer susceptibility candidate 3
HGNC id 17040
Location 17q21.1      Physical location : 38.296.506 - 38.328.432
Synonym name
  • Barentsz protein
  • metastatic axillary lymph nodes, cDNA51
  • metastatic lymph node protein 51
  • protein CASC3
  • Synonym symbol(s) MLN51, BTZ
    DNA
    TYPE functioning gene
    STRUCTURE 31.93 kb     14 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 4198 - 703 - 2002 12080473
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    Reproductivefemale systemuterus  highly
     male systemtestis  highly
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • coiled coil domain may be involved in oligomerization
  • HOMOLOGY
    Homologene
    FAMILY
  • CASC3 family
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text
  • recruited into cytoplasmic aggregates known as stress granules (SGs)
  • basic FUNCTION
  • may play a role in mRNA transport
  • induced by CSF2, and is important in the proliferation of RA fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis (RA)
  • exon-junction-complex-component, functioning in stress-granule assembly
  • CASC3 and CSF2 are involved in the proliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons
  • component of the exon junction complex (EJC), which is assembled on spliced mRNAs and plays important roles in post-splicing events
  • INTERACTION
    DNA
    RNA
    small molecule
    protein BLZF1 and CASC3 are further substrates targeted by tankyrase and RNF146 for degradation
    cell & other
    REGULATION
    induced by CSF2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancers and metastasis, as well as in gastric cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS