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FLASH GENE
Symbol CARS contributors: mct - updated : 08-04-2019
HGNC name cysteinyl-tRNA synthetase
HGNC id 1493
Corresponding disease
CARSD CARS deficiency
Location 11p15.4      Physical location : 3.022.151 - 3.078.681
Synonym name cysteine translase
Synonym symbol(s) SYC, CYSRS, CARS1, MGC:11246
EC.number 6.1.1.16
DNA
TYPE functioning gene
STRUCTURE 56.53 kb     22 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
22 splicing 2550 - 748 - 2016 26184909
unique 44 AAs C terminus
22 splicing 2558 - 726 - 2016 26184909
unique 22 AAs C terminus
23 - 2799 - 831 - 2016 26184909
23 - 2807 - 809 - 2016 26184909
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Urinarykidney   highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer monomer
HOMOLOGY
interspecies homolog to murine Cars
Homologene
FAMILY aminoacyl-tRNA synthetase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • fusion partner of anaplastic lymphoma kinase in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor cases
  • loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation
  • is the sole enzyme responsible for charging tRNACys molecules in the cytoplasm of mammalian cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding to tRNA
    small molecule metal binding,
    one zinc ion per subunit
    protein cysteine
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CARSD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    fused with ALK in t(2;11;2) (p23;p15;q31) in inflammatory mesenchymal tumors
    Susceptibility
  • to immune disease polymyositis/dermatomyositis
  • susceptibility to diabetic nephropathy in type 1 diabetes
  • Variant & Polymorphism SNP , other
  • strong association was identified at the CARS (cysteinyl-tRNA synthetase) locus with susceptibility to diabetic nephropathy in type 1 diabetes
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS