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FLASH GENE
Symbol CARS contributors: mct - updated : 08-04-2019
HGNC name cysteinyl-tRNA synthetase
HGNC id 1493
Corresponding disease
CARSD CARS deficiency
Location 11p15.4      Physical location : 3.022.151 - 3.078.681
Synonym name cysteine translase
Synonym symbol(s) SYC, CYSRS, CARS1, MGC:11246
EC.number 6.1.1.16
DNA
TYPE functioning gene
STRUCTURE 56.53 kb     22 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
TNNT3 11p15.5 troponin T3, skeletal, fast MRPL23 11p15.5 mitochondrial ribosomal protein L23 LOC387743 11 LOC387743 H19 11p15.5 H19, imprinted maternally expressed untranslated mRNA IGF2 11p15.5 insulin-like growth factor 2 (somatomedin A) IGF2AS 11p15.5 insulin-like growth factor 2, antisense INS 11p15.5 insulin TH 11p15.5 tyrosine hydroxylase ASCL2 11p15.5 achaete-scute complex-like 2 (Drosophila) C11orf21 11p15.5 chromosome 11 open reading frame 21 PHEMX 11p15.5 pan-hematopoietic expression CD81 11p15.5 CD81 antigen (target of antiproliferative antibody 1) TSSC4 11p15.5 tumor suppressing subtransferable candidate 4 TRPM5 11p15.5 transient receptor potential cation channel, subfamily M, member 5 KCNQ1 11p15.5 potassium voltage-gated channel, KQT-like subfamily, member 1 CDKN1C 11p15.5 cyclin-dependent kinase inhibitor 1C (p57, Kip2) HSA404617 11p15.5 BWRT protein SLC22A1LS 11p15.5 solute carrier family 22 (organic cation transporter), member 1-like antisense SLC22A1L 11p15.5 solute carrier family 22 (organic cation transporter), member 1-like PHLDA2 11p15.5 pleckstrin homology-like domain, family A, member 2 NAP1L4 11p15.5 nucleosome assembly protein 1-like 4 PRO0943 11p15.5 hypothetical protein PRO0943 CARS 11p15.5 cysteinyl-tRNA synthetase OSBPL5 11p15.4 oxysterol binding protein-like 5 FLJ36102 11p15.5 hypothetical protein FLJ36102 MRGE 11p15.5 mas-related G protein-coupled MRGE ZNF195 11p15.5 zinc finger protein 195 OR7E12P 11p15.5 olfactory receptor, family 7, subfamily E, member 12 pseudogene LOC387744 11 similar to asparagine-linked glycosylation 1 homolog (yeast, beta-1,4-mannosyltransferase); beta-1,4 mannosyltransferase LOC387745 11 similar to hypothetical protein SB153 LOC387746 11 LOC387746 LOC341141 11p15.5 similar to seven transmembrane helix receptor TRPC2 11p15.4-p15.3 transient receptor potential cation channel, subfamily C, member 2 ART5 11p15.5 ADP-ribosyltransferase 5 ART1 11p15.5 ADP-ribosyltransferase 1 CHRNA10 11p15.5 cholinergic receptor, nicotinic, alpha polypeptide 10 NUP98 11p15.5 nucleoporin 98kDa FRAG1 11p15.5 nucleoporin 98kDa ARHG 11p15.5-p15.4 ras homolog gene family, member G (rho G) STIM1 11p15.5 stromal interaction molecule 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
22 splicing 2550 - 748 - 2016 26184909
unique 44 AAs C terminus
22 splicing 2558 - 726 - 2016 26184909
unique 22 AAs C terminus
23 - 2799 - 831 - 2016 26184909
23 - 2807 - 809 - 2016 26184909
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Urinarykidney   highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer monomer
HOMOLOGY
interspecies homolog to murine Cars
Homologene
FAMILY aminoacyl-tRNA synthetase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • fusion partner of anaplastic lymphoma kinase in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor cases
  • loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation
  • is the sole enzyme responsible for charging tRNACys molecules in the cytoplasm of mammalian cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding to tRNA
    small molecule metal binding,
    one zinc ion per subunit
    protein cysteine
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CARSD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    fused with ALK in t(2;11;2) (p23;p15;q31) in inflammatory mesenchymal tumors
    Susceptibility
  • to immune disease polymyositis/dermatomyositis
  • susceptibility to diabetic nephropathy in type 1 diabetes
  • Variant & Polymorphism SNP , other
  • strong association was identified at the CARS (cysteinyl-tRNA synthetase) locus with susceptibility to diabetic nephropathy in type 1 diabetes
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS