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FLASH GENE
Symbol CARNS1 contributors: mct/npt - updated : 28-04-2010
HGNC name carnosine synthase 1
HGNC id 29268
Location 11q13.2      Physical location : 67.183.148 - 67.193.076
Synonym name ATP-grasp domain containing 1
Synonym symbol(s) ATPGD1, KIAA1394
EC.number 6.3.2.11
DNA
TYPE functioning gene
STRUCTURE 9.93 kb     9 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 3983 - 950 - Drozak (2010)
9 - 3956 - 827 - Drozak (2010)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousbrain    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two ATP-grasp domains, with highest conservation in the C-terminal catalytic domain (Drozak 2010)
  • HOMOLOGY
    Homologene
    FAMILY
  • ATP-grasp family of ATPases
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • involved in synthese of carnosine from beta-alanine and l-histidine (Drozak 2010)
  • catalyzes the hydrolysis of ATP to ADP rather than to AMP as previously assumed (Drozak 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS