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FLASH GENE
Symbol CARM1 contributors: mct/pgu - updated : 25-11-2015
HGNC name coactivator-associated arginine methyltransferase 1
HGNC id 23393
Location 19p13.2      Physical location : 10.982.252 - 11.033.447
Synonym name protein arginine N-methyltransferase 4
Synonym symbol(s) PRMT4
EC.number 2.1.1.125
DNA
TYPE functioning gene
STRUCTURE 51.20 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
LOC388504 19 LOC388504 MRPL4 19p13.2 mitochondrial ribosomal protein L4 ICAM1 19p13.3-p13.2 intercellular adhesion molecule 1 (CD54), human rhinovirus receptor ICAM4 19p13.2-cen intercellular adhesion molecule 4, Landsteiner-Wiener blood group ICAM5 19p13.2 intercellular adhesion molecule 5, telencephalin LOC388505 MGC19604 19p13.2 similar to RIKEN cDNA B230118G17 gene RAVER1 19p13.2 RAVER1 ICAM3 19p13.3-p13.2 intercellular adhesion molecule 3 TYK2 19p13.2 tyrosine kinase 2 CDC37 19p13.2 CDC37 cell division cycle 37 homolog (S. cerevisiae) PDE4A 19p13.2 phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila) KEAP1 19p13.2 kelch-like ECH-associated protein 1 EDG8 19p13.2 endothelial differentiation, sphingolipid G-protein-coupled receptor, 8 AUTL4 19p13.2 AUT-like 4, cysteine endopeptidase (S. cerevisiae) FLJ12949 19p13.2 hypothetical protein FLJ12949 CDKN2D 19p13.2 cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) AP1M2 19p13.2 adaptor-related protein complex 1, mu 2 subunit CTL2 19p13.1 adaptor-related protein complex 1, mu 2 subunit ILF3 19p13 interleukin enhancer binding factor 3, 90kDa QTRT1 19p13.3 queuine tRNA-ribosyltransferase 1 (tRNA-guanine transglycosylase) DNM2 19p13.2 dynamin 2 IL1RL1LG 19p13.2 interleukin 1 receptor-like 1 ligand LOC255809 19p13.2 hypothetical LOC255809 CARM1 19p13.2 hypothetical LOC255809 MGC3262 19p13.2 hypothetical protein MGC3262 LOC90580 19p13.2 hypothetical protein BC011833 SMARCA4 19p13.2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 LDLR 19p13.2 low density lipoprotein receptor (familial hypercholesterolemia) FLJ90806 KIAA1518 LOC55908 19p13.2 hepatocellular carcinoma-associated gene TD26 TM4-B 19p13.2 tetraspanin TM4-B RAB3D 19p13.2 RAB3D, member RAS oncogene family LPPR2 19p13.2 lipid phosphate phosphatase-related protein type 2 UNQ501 19p13.2 MBC3205 LOC126075 19p13.2 hypothetical protein LOC126075 FLJ35119 19p13.2 hypothetical protein FLJ35119 EPOR 19p13.2 erythropoietin receptor RGL3 19p13.1-p13.2 erythropoietin receptor MGC20983 19p13.2 hypothetical protein MGC20983
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 2968 65 608 - 2005 15616592
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
 stomach   highly
Endocrineparathyroid   moderately
Nervousnerve   highly
Reproductivefemale systemovary  moderately
 female systembreastmammary gland moderately
 female systemuteruscervix highly
 male systemprostate   
Respiratorylung   moderately
 respiratory tractlarynx  highly
Visualeye   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
cell lineage
cell lines
fluid/secretion moderately in lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N- and C-terminal regions required for enhancement of transcriptional activation by nuclear receptors
  • C-terminal part containing an autonomous activation domain, suggesting that it interacts with other proteins that help to mediate coactivator function
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Carm1 (98.2pc)
    homolog to rattus Prmt4 (98.2pc)
    intraspecies homolog to PRMT1
    Homologene
    FAMILY
  • P160 protein family
  • protein arginine N-methyltransferase family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text phosphorylation at Ser217 promoted CARM1 cytoplasmic localization and this translocation occurred mainly during mitosis
    basic FUNCTION
  • arginine methyltransferase transferring a methylgroup from S adenosylmethionine to the guanidino group nitrogen atoms of specific proteins
  • playing a significant role in promoting the differentiation of early thymocyte progenitors
  • functioning as a transcriptional coactivator for E2F1/DP1-stimulated expression of CCNE1 and DHFR
  • transcriptional coactivator of NF-kappaB and functioning as a promoter-specific regulator of NF-kappaB recruitment to chromatin
  • is recruited to gene promoters by many transcription factors
  • regulating adipose tissue biology by acting as a coactivator of PPARgamma
  • promoting adipocyte differentiation by coactivating PPARgamma-mediated transcription and thus might be important in energy balance
  • being a positive regulator of ER alpha-mediated transcriptional activation by cAMP
  • cooperating with PRMT1 in gene regulation
  • can function as a secondary coactivator for nuclear receptor-mediated transcription by methylating arginine residues 17 and 26 of histone H3
  • could be a protein that shuttles between the nucleus and cytoplasm
  • its automethylation provides a direct link to couple transcription and pre-mRNA splicing in a manner differing from the other steroid receptor coactivators
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with EP300 and NF-kappaB and interacting directly with the NF-kappaB subunit p65
  • part of a complex consisting of CARM1, EP300/P300 and NCOA2/GRIP1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with the C-terminus of NCOA2/GRIP1, NCO3/ACTR and NCOA1/SRC1
  • interacting with FLII, TP53, myogenic factor MEF2, EP300/P300, CREBBP and CTNNB1
  • interacting with SNRPC
  • interacting with NR1H4
  • interacting with RELA
  • interacting with HTLV-1 Tax-1
  • binding to histone H3, fibrillarin nucleolin, hnRNPA1
  • transcriptional coactivator of the androgen receptor (AR), involved in the regulation of the biologic functions of the AR
  • PELP1-CARM1 interactions synergistically enhance ESR1 transactivation
  • CARM1 catalyzes the methylation of ELAVL1
  • CARM1 represses replicative senescence by methylating ELAVL1 and thereby enhancing ELAVL1 ability to regulate the turnover of CCNA1, CCNB1, FOS, SIRT1, and CDKN2A mRNAs (
  • JMJD6 is necessary for MED12 to interact with CARM1, which methylates MED12 at multiple arginine sites and regulates its chromatin binding
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate carcinoma as well as androgen-independent prostate carcinoma
    tumoral     --over  
    in high-grade prostatic intraepithelial neoplasia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • being a potential new target in the treatment of estrogen-dependent breast cancer
  • SystemTypeDisorderPubmed
    cancerreproductivebreast
    potential new target in the treatment of estrogen-dependent breast cancer
    ANIMAL & CELL MODELS
    loss of estrogen receptor (ER) activity in CARM1-deficient mouse embryonic fibroblast cells