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FLASH GENE
Symbol CARM1 contributors: mct/pgu - updated : 25-11-2015
HGNC name coactivator-associated arginine methyltransferase 1
HGNC id 23393
Location 19p13.2      Physical location : 10.982.252 - 11.033.447
Synonym name protein arginine N-methyltransferase 4
Synonym symbol(s) PRMT4
EC.number 2.1.1.125
DNA
TYPE functioning gene
STRUCTURE 51.20 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 2968 65 608 - 2005 15616592
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
 stomach   highly
Endocrineparathyroid   moderately
Nervousnerve   highly
Reproductivefemale systemovary  moderately
 female systembreastmammary gland moderately
 female systemuteruscervix highly
 male systemprostate   
Respiratorylung   moderately
 respiratory tractlarynx  highly
Visualeye   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
cell lineage
cell lines
fluid/secretion moderately in lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N- and C-terminal regions required for enhancement of transcriptional activation by nuclear receptors
  • C-terminal part containing an autonomous activation domain, suggesting that it interacts with other proteins that help to mediate coactivator function
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Carm1 (98.2pc)
    homolog to rattus Prmt4 (98.2pc)
    intraspecies homolog to PRMT1
    Homologene
    FAMILY
  • P160 protein family
  • protein arginine N-methyltransferase family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text phosphorylation at Ser217 promoted CARM1 cytoplasmic localization and this translocation occurred mainly during mitosis
    basic FUNCTION
  • arginine methyltransferase transferring a methylgroup from S adenosylmethionine to the guanidino group nitrogen atoms of specific proteins
  • playing a significant role in promoting the differentiation of early thymocyte progenitors
  • functioning as a transcriptional coactivator for E2F1/DP1-stimulated expression of CCNE1 and DHFR
  • transcriptional coactivator of NF-kappaB and functioning as a promoter-specific regulator of NF-kappaB recruitment to chromatin
  • is recruited to gene promoters by many transcription factors
  • regulating adipose tissue biology by acting as a coactivator of PPARgamma
  • promoting adipocyte differentiation by coactivating PPARgamma-mediated transcription and thus might be important in energy balance
  • being a positive regulator of ER alpha-mediated transcriptional activation by cAMP
  • cooperating with PRMT1 in gene regulation
  • can function as a secondary coactivator for nuclear receptor-mediated transcription by methylating arginine residues 17 and 26 of histone H3
  • could be a protein that shuttles between the nucleus and cytoplasm
  • its automethylation provides a direct link to couple transcription and pre-mRNA splicing in a manner differing from the other steroid receptor coactivators
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with EP300 and NF-kappaB and interacting directly with the NF-kappaB subunit p65
  • part of a complex consisting of CARM1, EP300/P300 and NCOA2/GRIP1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with the C-terminus of NCOA2/GRIP1, NCO3/ACTR and NCOA1/SRC1
  • interacting with FLII, TP53, myogenic factor MEF2, EP300/P300, CREBBP and CTNNB1
  • interacting with SNRPC
  • interacting with NR1H4
  • interacting with RELA
  • interacting with HTLV-1 Tax-1
  • binding to histone H3, fibrillarin nucleolin, hnRNPA1
  • transcriptional coactivator of the androgen receptor (AR), involved in the regulation of the biologic functions of the AR
  • PELP1-CARM1 interactions synergistically enhance ESR1 transactivation
  • CARM1 catalyzes the methylation of ELAVL1
  • CARM1 represses replicative senescence by methylating ELAVL1 and thereby enhancing ELAVL1 ability to regulate the turnover of CCNA1, CCNB1, FOS, SIRT1, and CDKN2A mRNAs (
  • JMJD6 is necessary for MED12 to interact with CARM1, which methylates MED12 at multiple arginine sites and regulates its chromatin binding
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate carcinoma as well as androgen-independent prostate carcinoma
    tumoral     --over  
    in high-grade prostatic intraepithelial neoplasia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • being a potential new target in the treatment of estrogen-dependent breast cancer
  • SystemTypeDisorderPubmed
    cancerreproductivebreast
    potential new target in the treatment of estrogen-dependent breast cancer
    ANIMAL & CELL MODELS
    loss of estrogen receptor (ER) activity in CARM1-deficient mouse embryonic fibroblast cells