Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CARD8 contributors: mct/npt - updated : 09-10-2019
HGNC name caspase recruitment domain family, member 8
HGNC id 17057
Location 19q13.33      Physical location : 48.711.343 - 48.759.203
Synonym name
  • CARD inhibitor of NF-Kappa B-activating ligands
  • tumor upregulated CARD-containing antagonist of caspase nine
  • apoptotic protein NDPP1
  • Synonym symbol(s) DACAR, NDPP1, TUCAN, CARDINAL, KIAA0955 , FLJ18119, FLJ18121, DKFZp779L0366, MGC57162
    DNA
    TYPE functioning gene
    STRUCTURE 53.12 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text 5 splice variants (Zhang, 2002)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 5610 - 537 - 2002 11956601
    10 - 5166 - 287 - 2002 11956601
    11 - 2567 - 359 - 2002 11956601
    4 - 634 - 70 - 2002 11956601
    11 - 5207 - 342 - 2002 11956601
    13 - 5501 - 425 - 2002 11956601
    12 - 5818 - 342 - 2002 11956601
    11 - 5277 - 287 - 2002 11956601
    12 - 5419 - 432 - 2002 11956601
    13 - 5460 - 487 - 2002 11956601
    12 - 5427 - 311 - 2002 11956601
    13 - 5468 - 392 - 2002 11956601
    15 - 5917 - 537 - 2002 11956601
    13 - 5491 - 487 - 2002 11956601
    11 - 5238 - 487 - 2002 11956601
    11 - 5246 - 392 - 2002 11956601
    11 - 5276 - 431 - 2002 11956601
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine    
    Endocrinethyroid   highly
    Lymphoid/Immunelymph node   predominantly
     spleen   moderately
     thymus   highly
    Nervousnerve   moderately
    Reproductivemale systemtestis   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a CARD recruitment domain
  • a segment of homology to the C terminus of DEFCAP/NAC
  • mono polymer homomer , dimer
    HOMOLOGY
    intraspecies paralog to H2
    Homologene
    FAMILY
  • CARD family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • antagonist of caspase 9, inhibitor of multiple NF-Kappa B activation pathways, and negative regulator of cell death and inflammatory response
  • implicated in the regulation of apoptosis and inflammation
  • acting as a new signaling molecule involved in the regulation of caspase-1 and NF-kappaB activation
  • plays crucial roles in regulating apoptotic and inflammatory signaling pathways through the association of its caspase-recruitment domain (CARD) with those of procaspase-9 and procaspase-1
  • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    text inhibitor of apoptosis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • the regulatory subunit of the IKK complex, IKBKG (NEMO)
  • CASP9, CASP1 suppressing caspase activator induced by the APAF1 activator, cytochrome C
  • ICEBERG
  • COP1
  • DRAL
  • pseudo-ICE
  • FNBP3
  • NALP2 NACHT domain
  • CARD8 physically interacts with NOD2 and inhibits nodosome assembly and subsequent signaling upon muramyl-dipeptide stimulation
  • CARD8 is a downstream target gene regulated by CDKN2BAS1
  • CDKN2B-AS1 may increase the risk of ischemic stroke through regulation of the CARD8 pathway
  • is a negative regulator for NLRP3 inflammasome
  • cytosolic serine dipeptidyl peptidases DPP8 and DPP9 suppress inflammasome activation upstream of NLRP1 and CARD8 in human keratinocytes and peripheral blood mononuclear cells
  • DPP9 binds directly to NLRP1 and CARD8, and this interaction may contribute to the inhibition of NLRP1
  • cell & other
    REGULATION
    Other function of CARD8 may be regulated by both intramolecular and intermolecular interactions involving electrostatic attractions
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cancer with shorter patient survival
    Susceptibility
  • to Crohn disease
  • to inflammatory bowel disease
  • to cardiovascular diseases
  • to chronic myeloid leukemia (CML)
  • to preeclampsia (PE)
  • Variant & Polymorphism other
  • association between CARD8 and a likely functional polymorphism in Crohn disease
  • CARD8 variants might have roles in the pathogenesis of inflammatory bowel disease in Koreans
  • AT genotype of CARD8 (rs2043211) was significantly higher compared to TT genotype in high and intermediate risk CML patients
  • polymorphism of rs2043211 in CARD8 may be a relevant host susceptibility factor for the development of PE
  • CARD8 rs2043211 polymorphism is associated with cardiovascular diseases
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS