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FLASH GENE
Symbol CARD18 contributors: mct/ - updated : 14-06-2008
HGNC name caspase recruitment domain family, member 18
HGNC id 28861
Location 11q22.3      Physical location : 105.008.447 - 105.010.461
Synonym name ICEBERG caspase-1 inhibitor
Synonym symbol(s) UNQ5804, ICEBERG, pseudo-ICE
DNA
TYPE functioning gene
STRUCTURE 1.14 kb     2 Exon(s)
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 670 10 90 - Lamkanfi (2004)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Reproductivefemale systemplacenta   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a CARD domain
  • HOMOLOGY
    Homologene
    FAMILY
  • death-domain-fold superfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • cysteine protease inhibitor activity
  • inhibiting the generation of IL1B by interacting with caspase 1 and preventing its association with RIP2
  • may be part of a negative feedback loop
  • regulating apoptosis
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CARD8
  • cell & other
    REGULATION
    induced by proinflammatory stimuli
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS