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FLASH GENE
Symbol CARD17 contributors: npt/ - updated : 18-07-2008
HGNC name caspase recruitment domain family, member 17
HGNC id 33827
Location 11q22.3      Physical location : 104.963.195 - 104.972.158
Synonym name
  • inhibitory caspase recruitment domain (CARD) protein
  • inhibitory CARD
  • Synonym symbol(s) INCA
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text
  • cluster of proinflammatory caspase genes and their inhibitors
  • STRUCTURE 8.96 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    regionally located . located between the genes of COP/Pseudo-ICE and ICEBERG
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 466 11 110 - Lamkanfi (2004)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid    
    Reproductivefemale systemplacenta  predominantly
     female systemuterus  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • caspase recruitment domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in the release of interleukin 1-beta by specific cleavage at 116-Asp
  • intracellular regulator of procaspase-1 activation, involved in the regulation of pro-IL-1beta processing and its release during inflammation (Lamkanfi 2004)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS