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FLASH GENE

Symbol

CARD16

contributors: mct/ - updated : 02-04-2008

HGNC name	caspase recruitment domain family, member 16
HGNC id	33701

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q22.3      Physical location : 104.912.052 - 104.916.051
Synonym name	caspase-1 dominant-negative inhibitor pseudo-ICE
	pseudo interleukin-1beta converting enzyme
	CARD only protein
	caspase-1 inhibitor COP
Synonym symbol(s)	COP, PSEUDO-ICE, COP1

DNA

TYPE	functioning gene
STRUCTURE	4.00 kb     4 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

regionally located

located near INCA

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001017534 3 splicing 695 NP_001017534 22.6 197 - Wang (2006) NM_052889 4 splicing 758 NP_443121 10.7 97 - Druilhe, Wang (2006) having an additional exon containing a stop codon in the middle region compared to variant 1

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   moderately Reproductive female system uterus cervix   predominantly   female system ovary     moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION

basic FUNCTION	may play a role in down-regulating inflammatory responses analogous to the CARD protein ICEBERG
	can regulate IL-1beta secretion

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

CARD8

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS