Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CAPZB contributors: mct - updated : 20-11-2018
HGNC name capping protein (actin filament) muscle Z-line, beta
HGNC id 1491
Location 1p36.13      Physical location : 19.665.266 - 19.812.066
Synonym name
  • F-actin capping protein beta subunit
  • CapZ beta
  • capping protein (actin filament) muscle Z-line, beta
  • epididymis secretory sperm binding protein
  • Synonym symbol(s) CAPB, CAPZ, CAPPB, MGC104401, MGC129749
    DNA
    TYPE functioning gene
    STRUCTURE 146.87 kb     9 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    MGC15730 1p36.13 hypothetical protein MGC15730 FLJ38753 1p36.13 hypothetical protein FLJ38753 LOC391012 1 similar to Putative dynein light chain protein DJ8B22.1 PAX7 1p36.2-p36.12 paired box gene 7 TAS1R2 1p36.13 taste receptor, type 1, member 2 ALDH4A1 1p36 aldehyde dehydrogenase 4 family, member A1 RBAF600 1p36.13 retinoblastoma-associated factor 600 KIAA0090 1p36.13 retinoblastoma-associated factor 600 C1orf33 1p36.13 chromosome 1 open reading frame 33 AFAR3  aflatoxin B1 aldehyde reductase 3 AKR7A3 1p35.1-p36.23 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) AKR7A2 1p36.1-p35 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) FLJ20320 CAPZB 1p36.1 capping protein (actin filament) muscle Z-line, beta LOC388600 1 similar to protein of fungal metazoan origin like (11.1 kD) (2C514) NBL1 1p36.13-p36.11 neuroblastoma, suppression of tumorigenicity 1 HTR6 1p36-p35 5-hydroxytryptamine (serotonin) receptor 6 LOC255104 1p36.13 hypothetical protein LOC255104 FLJ20225 1p36.13 hypothetical protein FLJ20225 LOC254897 1p36.13 similar to OSJNBa0043A12.32 PLA2G2E 1p36.13 similar to OSJNBa0043A12.32 PLA2G2A 1p36.1-p35 phospholipase A2, group IIA (platelets, synovial fluid) PLA2G5 1p36-p34 phospholipase A2, group V PLA2G2D 1p36.12 phospholipase A2, group IID PLA2G2F 1p35 phospholipase A2, group IID LOC391013 1 similar to Group IIC secretory phospholipase A2 precursor (Phosphatidylcholine 2-acylhydrolase GIIC) (GIIC sPLA2) (PLA2-8) (14 kDa phospholipase A2) FLJ25429 FLJ32784 1p36.13 hypothetical protein FLJ32784 LOC388601 1 LOC388601 CaMKIINalpha 1p36.13 calcium/calmodulin-dependent protein kinase II FLJ12875 1p36.13 hypothetical protein FLJ12875 LOC163933 1p36.12 similar to cDNA sequence BC022623 CDA 1p36.2-p35 cytidine deaminase PINK1 1p36 PTEN induced putative kinase 1 DDOST 1p36.1 dolichyl-diphosphooligosaccharide-protein glycosyltransferase KIF17 1p36.13 kinesin family member 17
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1728 - 272 - 2017 28104696
    10 - 1910 - 277 - 2017 28104696
    9 - 2217 - 260 - 2017 28104696
    5 - 829 - 112 - 2017 28104696
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Reproductivefemale systembreastmammary gland highly
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • beta subunit of the barbed end actin binding protein
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Cappb1
    Homologene
    FAMILY
  • f-actin capping protein beta subunit family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • involved in the regulation of growth of the actin filament by capping the barbed end of growing actin filaments
  • CAPZB and PDE8B have been linked to TSH levels
  • is an actin-capping protein that caps the growing end of F-actin and modulates the cytoskeleton and tethers actin filaments to the Z-line of the sarcomere in muscles
  • actin filament length regulators CFL1, CAPZB and DIAPH1 regulate mitotic cortex thickness and both increasing and decreasing thickness decreases tension in mitosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer of an alpha and a beta subunit
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • QKI promotes inclusion of CAPZB exon 9 in opposition to repression by polypyrimidine tract-binding protein (PTB)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    silencing of CAPZB inhibited the growth, invasion and migration of epithelioid sarcoma
    Susceptibility to TSH variation
    Variant & Polymorphism SNP
  • rs10917469, located near CAPZB is assocaiated to TSH variation
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    may be a potential therapeutic target in epithelioid sarcoma
    ANIMAL & CELL MODELS