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FLASH GENE
Symbol CAPZA1 contributors: npt/mct - updated : 22/10/2008
HGNC name capping protein (actin filament) muscle Z-line, alpha 1
HGNC id 1488
Location 1p13.2      Physical location : 113.162.074 - 113.214.241
Synonym name
  • CAP protein, actin, alpha 1 subunit
  • CapZ alpha-1
    • Synonym symbol(s) CAPZ, CAZ1, CAPPA1
    DNA
    TYPE like-sequence
    STRUCTURE 52.16 kb     10 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2758 32 286 - Ewing (2007)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    secondary structure an alpha and beta subunit
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Cappa1
    intraspecies homolog to capzaz
    Homologene
    FAMILY
  • F-actin capping protein alpha subunit family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION playing a critical role for actin binding
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS