Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CAPRIN2 contributors: mct - updated : 21-12-2010
HGNC name caprin family member 2
HGNC id 21259
Location 12p11.21      Physical location : 30.862.485 - 30.907.448
Synonym name
  • growth-related gene 1
  • C1q domain containing 1
  • cytoplasmic activation/proliferation-associated protein 2
  • gastric cancer multidrug resistance-associated protein
  • RNA granule protein 140
  • Synonym symbol(s) EEG1, FLJ22569, FLJ11391, C1QDC1, FLJ22569, MGC102894, MGC134847, MGC134848, KIAA1873, RNG140, EEG-1L
    DNA
    TYPE functioning gene
    STRUCTURE 44.96 kb     18 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 4351 121 1077 - 2004 14593112
    also called isoform L
    - - 4414 31 278 - 2004 14593112
    18 - 4501 125.9 1127 - 2004 14593112
    also called variant 1
    17 - 4415 - 793 - 2004 14593112
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly Homo sapiens
     brainhindbraincerebellum highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    NervousPurkinje cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal region is a major RNA-binding site, consistent with findings in CAPRIN1
  • basic helices and RGG boxes (basic helix region responsible of translation repression activity)
  • C-terminal domain, which is homologous to the globular domain of complement component C1q of the immune system
  • HOMOLOGY
    interspecies homolog to murine C1qdc1
    intraspecies paralog to CAPRIN1
    Homologene
    FAMILY
  • complement C1q protein family
  • caprin family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus
    text localized to dendritic RNA granules in neurons, but the granules were distinct from CAPRIN1-containing RNA granules
    basic FUNCTION
  • probably involved in the regulation of growth of erythroblasts during the terminal phase of differenciation
  • promotes activation of the canonical Wnt signaling pathway by regulating LRP5/6 phosphorylation
  • RNA-binding protein, which was present in RNA granules that were distinct from CAPRIN1-containing RNA granules
  • CAPRIN1, and CAPRIN2 induce the formation of RNA granules
  • but is a RNA-binding protein that shows different expression and localization patterns from CAPRIN1
  • having roles in the maintenance of the dendritic structure in the adult vertebrate brain through localizing to a kind of RNA granules that are distinct from CAPRIN1-containing granules
  • may be playing roles in the maintenance of dendritic structure through different mechanisms from CAPRIN1
  • stabilizes cytosolic beta-catenin and enhances lymphoid enhancer-binding factor 1/T cell factor-dependent reporter gene activity as well as the expression of Wnt target genes in mammalian cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA RNA-binding protein
    small molecule
    protein
  • LRP5/6-binding protein
  • cell & other
    REGULATION
    inhibited by FGF signals which induce the newly characterized protein CAPRIN2 in the lens
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS