Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CAPRIN1 contributors: mct/ - updated : 07-12-2011
HGNC name cell cycle associated protein 1
HGNC id 6743
Location 11p13      Physical location : 34.073.229 - 34.124.157
Synonym name
  • cytoplasmic activation/proliferation-associated protein-1
  • glycosyl-phosphatidylinositol-anchored membrane protein p137
  • membrane component, chromosome 11, surface marker 1
  • caprin 1
  • RNA granule protein 105
  • activation/proliferation-associated protein 1
  • GPI-anchored membrane protein 1
  • Synonym symbol(s) GPIP137, M11S1, GPIAP1, M11S1, caprin-1, p137GPI, RNG105
    DNA
    TYPE functioning gene
    STRUCTURE 50.93 kb     19 Exon(s)
    MAPPING cloned Y linked N status provisional
    regionally located 300 kb telomeric of CAT (115500) and 200 kb centromeric to the LIM-domain only 2 gene
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 5562 78 709 - -
    19 exons
    18 - 3553 76 694 - -
  • 18 exons
  • differs in the 3' UTR and coding region compared to variant 1
  • the resulting isoform is shorter and has a distinct C-terminus compared to isoform 1
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Nervousbrain     Homo sapiens
    Reproductivemale systemtestis  highly
    Respiratoryrespiratory tracttrachea  highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveenterocyte
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text highly expressed in embryonic brains
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two basic domains, N-terminal basic helices (coiled-coil) and C-terminal RGG boxes (RG-rich region), which are responsible for RNA binding and for RNA granule formation
  • several alpha helices in the N terminal region
  • homology regions-1 and -2 (HR-1, HR-2), and HR1 appeared necessary for formation of multimeric complexes of CAPRIN1
  • middle proline and glutamine rich repeats
  • a GPI anchor site at the C terminus, selectively bound mRNA for c-Myc or cyclin D2
  • conjugated GlycoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to murine Gpiap1
    ortholog to rattus Gpiap1
    intraspecies paralog to CAPRIN2
    Homologene
    FAMILY
  • caprin family
  • CATEGORY antigen , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    text
  • attached to the membrane by a GPI-anchor
  • localized to dendritic RNA granules, to neuronal RNA granules in dendrites
  • basic FUNCTION
  • playing a role in transporting nutrient from the gut lumen across the gutlining epithelial cell layer
  • plays a role in cellular activation or proliferation
  • may be having a role in mRNA transport and local translational control
  • CAPRIN1, and CAPRIN2 induce the formation of RNA granules
  • RNA-binding protein, has previously been identified as a component of RNA granules that mediate dendritic mRNA localization and local translation
  • role in the dendritic localization of mRNAs
  • formation of CAPRIN1-containing stress granules is a key damage response to a clinically relevant ototoxic agent
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS digestion
    PATHWAY
    metabolism
    signaling
    a component
  • protein constituent of membrane
  • homodimer disulfide-linked
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with G3BP1 (Caprin-1/G3BP1 complex is likely to regulate the transport and translation of mRNAs of proteins involved with synaptic plasticity in neurons and cellular proliferation and migration in multiple cell types)
  • downregulated by POU4F3
  • cell & other
    REGULATION
    induced by in cochlear hair cells following aminoglycoside-induced damage
    repressed by MIR16-1 that negatively regulate two new targets, HMGA1 and caprin-1, which are involved in cell proliferation) (
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    affects the formation and maintenance of synapses and neuronal networks
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS