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FLASH GENE
Symbol CAPN9 contributors: npt/mct - updated : 22/10/2008
HGNC name calpain 9
HGNC id 1486
Location 1q42.2      Physical location : 230.883.129 - 230.937.749
Synonym name
  • novel calpain large subunit-4
  • digestive tract-specific calpain
  • CG36 protein
  • novel calpain large subunit-4
  • Synonym symbol(s) nCL-4, GC36
    EC.number 3.4.22.17
    DNA
    TYPE functioning gene
    STRUCTURE 54.62 kb     20 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 2362 79 690 - Davis (2007)
    19 - 2484 - 664 - Davis (2007)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
     pharynx   highly
     stomach    
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal regulatory domain processed after activation (I)
  • a cysteine protease domain (II)
  • a linker domain (III)
  • a calcium binding domain with calmodulin-like EF hand motifs (IV)
  • mono polymer heteromer , dimer
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • calcium dependent neutral cysteine protease (non-lysosomal) family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • heterodimerizing with a small subunit
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS