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FLASH GENE
Symbol CAPN9 contributors: npt/mct - updated : 22/10/2008
HGNC name calpain 9
HGNC id 1486
Location 1q42.2      Physical location : 230.883.129 - 230.937.749
Synonym name
  • novel calpain large subunit-4
  • digestive tract-specific calpain
  • CG36 protein
  • novel calpain large subunit-4
  • Synonym symbol(s) nCL-4, GC36
    EC.number 3.4.22.17
    DNA
    TYPE functioning gene
    STRUCTURE 54.62 kb     20 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391175 1 similar to 60S ribosomal protein L23a HIST3H2A 1q42.13 histone 3, H2a HIST3H2BB 1q42.13 histone 3, H2bb HIST3H2BA 1 histone 3, H2ba LOC149603 1q42.13 hypothetical protein LOC149603 FLJ31401 1q42.13 hypothetical protein FLJ31401 LOC388750 1 similar to Ferritin heavy chain (Ferritin H subunit) ARHU 1q42.11-q42.3 ras homolog gene family, member U LOC388751 1 LOC388751 RAB4A 1q42-q43 RAB4A, member RAS oncogene family SPHAR 1q42.11-q42.3 S-phase response (cyclin-related) LOC126731 1q42.13 LOC126731 ACTA1 1q42.13-q42.2 actin, alpha 1, skeletal muscle NUP133 1q42.13 nucleoporin 133kDa ABCB10 1q42 ATP-binding cassette, sub-family B (MDR/TAP), member 10 TAF5L 1q42.13 TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa KIAA0133 1q42.13 TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa LOC391177 1 similar to HMG-1 LOC388752 1 LOC388752 GALNT2 1q41-q42 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2) PGBD5 1q42.13 piggyBac transposable element derived 5 COG2 1q41 component of oligomeric golgi complex 2 AGT 1q42-q43 angiotensinogen (serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 8) CAPN9 1q42.11-q42.3 calpain 9 (nCL-4) FLJ14525 1q42.13-q43 hypothetical protein FLJ14525 TTC13 1q42.2 tetratricopeptide repeat domain 13 ARV1 1q42.2 likely ortholog of yeast ARV1 MGC15887 1q42.2 hypothetical gene supported by BC009447 FLJ30430 1q42.2 hypothetical protein FLJ30430 DKFZp547B1713 1q42.2 hypothetical protein DKFZp547B1713 GNPAT 1q42.11-q42.3 glyceronephosphate O-acyltransferase EXOC8 1q42.2 exocyst complex component 8 DKFZP547N043 1q42.12-q43 hypothetical protein DKFZp547N043 EGLN1 1q42.1 egl nine homolog 1 (C. elegans) TSNAX 1q42.1 translin-associated factor X DISC1 1q42.1 disrupted in schizophrenia 1 SIPA1L2 1q42.2 signal-induced proliferation-associated 1 like 2 KIAA1383 1q42.2 KIAA1383 protein MGC13186 1q42.2 hypothetical protein MGC13186
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 2362 79 690 - Davis (2007)
    19 - 2484 - 664 - Davis (2007)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
     pharynx   highly
     stomach    
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal regulatory domain processed after activation (I)
  • a cysteine protease domain (II)
  • a linker domain (III)
  • a calcium binding domain with calmodulin-like EF hand motifs (IV)
  • mono polymer heteromer , dimer
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • calcium dependent neutral cysteine protease (non-lysosomal) family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • heterodimerizing with a small subunit
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS