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FLASH GENE
Symbol CAPN8 contributors: npt/mct - updated : 22/10/2008
HGNC name calpain 8
HGNC id 1485
Location 1q41      Physical location : 223.714.971 - 223.853.436
Synonym name calpain 8 (nCL-2)
Synonym symbol(s) nCL-2
DNA
TYPE functioning gene
STRUCTURE 53.00 kb     11 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - - 79.6 703 - Sorimachi
- - - 42.6 381 stomach Sorimachi
  • identical to N-terminal half of nCL-2
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal regulatory domain processed after activation (I)
  • a cysteine protease domain (II)
  • a linker domain (III)
  • a calcium binding domain
  • a calmodulin-like EF hand motifs (IV)
  • mono polymer heteromer , dimer
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • calcium dependent neutral cysteine protease family (non lysosomal)
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in membrane trafficking in the gastric surface mucus cells (pit cells)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • heterodimerizing with a small subunit
  • exists in both monomeric and homo-oligomeric forms
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS