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FLASH GENE
Symbol CAPN6 contributors: mct/npt - updated : 10-04-2010
HGNC name calpain 6
HGNC id 1483
Location Xq23      Physical location : 110.488.327 - 110.513.774
Synonym name
  • calpamodulin
  • calpain-like protease
  • calpain-like protease X-linked
  • Synonym symbol(s) CANPX, CAPNX, CalpM, DJ914P14.1
    EC.number 3.4.22.17
    DNA
    TYPE functioning gene
    STRUCTURE 25.42 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - DXS1105 - COL4A6 - COL4A5 - ACSL4 - GUCY2F - DXS1210 - PPP6C - TDGF3 - DXS287 - DXS7506 - CYP19X - PAK3 - CAPN6 - DCX DCX - DXS7012E - TRPC5 - DXS8110 - DXS1059 - qter
    Authors Srivastava (99)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 3604 - 641 - Rho (2008)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemplacenta  specific
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text only in placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal regulatory domain processed after activation, protein domain (II), linker (III)
  • lacks the active-site cysteine residues requisite for protease activity (Tonami 2007)
  • C terminal T domain (not containing a calmodulin-like EF hand motifs)
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to C.elegans sex determination gene tra3
    ortholog to murine Capn6
    Homologene
    FAMILY
  • papain superfamily, calcium dependent neutral cysteine protease (non lysosomal), nCL-3 type
  • peptidase C2 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • lacking protease activity
  • calcium-dependent intracellular nonlysosomal protease (Lee 2007)
  • microtubule-stabilizing protein expressed in embryonic tissues that may be involved in the regulation of microtubule dynamics and cytoskeletal organization (Tonami 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • heterodimerizing with a small unit
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in uterine cervical cancer tissue compared to normal tissue (Rho 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target novel therapeutic target for certain types of cancers (Rho 2008)
    ANIMAL & CELL MODELS