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FLASH GENE
Symbol CAPN11 contributors: npt/mct - updated : 22/10/2008
HGNC name calpain 11
HGNC id 1478
Location 6p12      Physical location : 44.126.547 - 44.152.139
Synonym name calcium-activated neutral proteinase 11
Synonym symbol(s) CANP 11
EC.number 3.4.22.-
DNA
TYPE functioning gene
STRUCTURE 25.59 kb     23 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
23 - 2785 80 702 - Dear (1999)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousnerve    
Reproductivemale systemtestis   
 male systemprostate   
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatozoa
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal regulatory domain processed after activation (i)
  • a cysteine protease domain (II)
  • a linker domain (III)
  • a calcium binding domain
  • four calmodulin-like EF hand motifs (IV)
  • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • papain superfamily
  • peptidase C2 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • calcium dependent, neutral cysteine proteinase (non-lysosomal)
  • may have a protease activity and calcium-binding ability
  • involved in regulating calcium-dependent signal transduction events during meiosis and sperm functional processes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • heterodimerizing with a small subunit
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS