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FLASH GENE
Symbol CAPN10 contributors: mct - updated : 24-05-2014
HGNC name calpain 10
HGNC id 1477
Location 2q37.3      Physical location : 241.526.132 - 241.557.122
Genatlas name calcium-activated neutral protease 10
Synonym symbol(s) KIAA1845
EC.number 3.4.22.17
DNA
TYPE functioning gene
STRUCTURE 12.37 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map see NIDDM1
Physical map
NDUFA10 12p NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa LOC389090 2 similar to seven transmembrane helix receptor LOC391495 2 similar to DNA-directed RNA polymerase II largest subunit LOC150681 2q37.3 similar to Olfactory receptor 6B3 LOC391496 2 similar to olfactory receptor family 9 subfamily S LOC150678 2q37.3 helicase/primase complex protein LOC150677 LOC391497 2 similar to ENSANGP00000007346 GPC1 2q37.3 glypican 1 ANKMY1 2q37.3 ankyrin repeat and MYND domain containing 1 LOC285193 2q37.3 similar to RIKEN cDNA 0710001B24 RNPEPL1 2q37.3 arginyl aminopeptidase (aminopeptidase B)-like 1 CAPN10 2q37.3 calpain 10 GPR35 2q37.3 G protein-coupled receptor 35 LOC285192 2q37.3 similar to aquaporin 11 AQP12 2q37.3 aquaporin 12 ATSV 2q37.3 axonal transport of synaptic vesicles AGXT 2q37.3 alanine-glyoxylate aminotransferase (oxalosis I; hyperoxaluria I; glycolicaciduria; serine-pyruvate aminotransferase) FLJ22671 2q37.3 hypothetical protein FLJ22671 LOC285188 2q37.3 similar to KIAA0445 protein FLJ00133 2q37.3 FLJ00133 protein MGC61716 2q37.3 hypothetical protein MGC61716 PASK 2q37.3 PAS domain containing serine/threonine kinase PPP1R7 2q37.3 protein phosphatase 1, regulatory subunit 7 LOC344525 2q37.3 similar to transmembrane protein 16C; chromosome 11 open reading frame 25 HDLBP 2q37.3 high density lipoprotein binding protein (vigilin) NEDD5 2q37. neural precursor cell expressed, developmentally down-regulated 5 FARP2 2q37.3 FERM, RhoGEF and pleckstrin domain protein 2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1017 15.3 138 - 1997 9396712
12 - 2626 75 672 - 2001 11375982
CAPN10-a
12 - 2450 - 544 - 1997 9396712
10 - 2161 58 517 - 2001 11375982
CAPN10-c
11 - 2357 - 513 - 1997 9396712
13 - 2669 - 444 - 1997 9396712
12 - 2608 - 274 - 1997 9396712
4 - 1304 15.6 139 - 1997 9396712
EXPRESSION
Rna function
  • mRNA level was elevated in pancreatic islets from patients with T2D compared with non-diabetic
  • Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   highly Homo sapiens
    Lymphoid/Immunespleen   highly
     thymus   highly
    Urinarykidney     Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text tissues, developing lens
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal regulatory domain processed after activation,protease domain (II), linker (III)
  • C terminal T domain,
  • calmodulin-like-calcium binding domain
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Capn10
    Homologene
    FAMILY
  • non lysosomal cysteine protease
  • peptidase family C2
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • putative regulator of glucose homeostasis, catalyzing limited proteolysis of substrates invloveld in cytoskeletal remodeling and signal transduction
  • first reported mitochondrially targeted calpain and is a mediator of mitochondrial dysfunction through the cleavage of Complex I subunits and activation of mitochondrial permeability transition
  • may potentially act as a regulator of insulin secretion
  • cysteine protease, implicated in the progression of multiple disease states
  • mitochondrial calpain that is involved in Ca(2+)-induced mitochondrial dysfunction
  • may require a special intracellular localization or interacting partner(s) to acquire proteolytic activity, or it functions by interacting with other proteins rather than through its proteolytic activity
  • mitochondrial calpain 10 is required for cell viability and its levels specifically decrease in aging kidney tissues when renal function decreases
  • is potentially required for renal function and is a biomarker of the aging kidney
  • may play an important role in the pathogenesis of impaired fasting glucose (IFG) or impaired glucose tolerance in essential hypertension patients
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component heterodimers of an invariant small subunit and variable large subunits
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein
  • with SLC2A4 (involved in GLUT4 vesicle trafficking)
  • GAEC1 regulates the expression of CAPN10 and TNRC6C which predicts survival in esophageal squamous cell carcinoma
  • cell & other
    REGULATION
    Other may be regulated by intronic SNP,UCSNP43
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in glucose-tolerant but not glucose-intolerant individuals in response to prolonged exposure to fat
    Susceptibility
  • to NIDDM1 (MIM601283) (rare in African people) with elevated free fatty acid levels, not major susceptibility gene
  • to polycystic ovary syndrome
  • to a worse prognosis in laryngeal cancer
  • Variant & Polymorphism SNP , other
  • complex relationship between polymorphism and disease, not proven to be causative
  • G/G variant of SNP-43 was associated with reduced insulin release in response to glucose in non-diabetic
  • (C) allele at SNP44 with increased risk of type 2 diabetes
  • UCSNP-63 genotype 12 seems to be related with a worse prognosis in laryngeal cancer
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS