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FLASH GENE
Symbol CAPG contributors: mct - updated : 23-11-2011
HGNC name capping protein (actin filament), gelsolin-like
HGNC id 1474
Location 2p11.2      Physical location : 85.621.870 - 85.637.676
Synonym symbol(s) MCP, AFCP, gCap39
DNA
TYPE functioning gene
STRUCTURE 15.80 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 1460 - 348 - 1994 7851883
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Endocrinepancreas    
Nervousbrain    
Reproductivemale systemprostate  highly
Respiratorylung   highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunemacrophage
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
three gelsolin-like repeats
HOMOLOGY
interspecies ortholog to murine Capg
homolog to C.elegans K06A4.3
Homologene
FAMILY gelsolin/villin protein family
CATEGORY structural protein
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton
intracellular,nucleus,nucleolus
intracellular,nuclear envelope
text
  • localization at the mother centriole in interphase, the mitotic spindle in mitosis and the midbody ring in abscission
  • basic FUNCTION
  • calcium-sensible protein reversibly blocking the barbed ends of actin filaments but not severing preforming actin filaments
  • playing an important role in macrophage function
  • gelsolin-family actin modulating protein involved in cell signalling, receptor-mediated membrane ruffling, phagocytosis and motility
  • playing a role in regulating cyto plasmic and/or nuclear structures through potential interactions with actin
  • role for nuclear CAPG in eliciting invasion, possibly through interfering with the cellular transcription machinery
  • potentially involved in regulation of filamentous actin in the nucleolus
  • is phosphorylation is required for its chromosomal DNA localization during mitosis
  • role as a mediator of cross-talk between the actin cytoskeleton and microtubule-based organelles that regulate cell division
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • binding to actin-cytoskeleton
  • NUP62, is an interaction partner of CAPG, also localized to the midbody ring at the end of abscission and colocalized with CAPG
  • interacting with NUTF2 and RAN (NUTF2 and RAN control nuclear import of the filamentous actin capping protein CAPG)
  • cell & other
    REGULATION
    activated by hypoxia (hypoxia stimulates expression of CAPG and GSN via HIF1A-dependent and -independent pathways, respectively, and this up-regulation may contribute to the increased motility of pulmonary artery smooth muscle cells under hypoxia)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer, especially in metastasizing breast cancer
    constitutional     --over  
    triggers an increase in cell motility
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS