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FLASH GENE
Symbol CAP2 contributors: mct - updated : 03-05-2017
HGNC name CAP, adenylate cyclase-associated protein, 2 (yeast)
HGNC id 20039
Location 6p22.3      Physical location : 17.393.735 - 17.558.021
Synonym name adenylyl cyclase-associated protein 2
Synonym symbol(s) 2810452G09Rik
DNA
TYPE functioning gene
STRUCTURE 164.29 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
JMJ 6p24-p23 jumonji homolog (mouse) DTNBP1 6p22.3 dystrobrevin binding protein 1 LOC346113 6p22.3 similar to ARP2/3 complex 21 kDa subunit (p21-ARC) (Actin-related protein 2/3 complex subunit 3) LOC391871 6 similar to malate dehydrogenase 1; malate dehydrogenase, soluble; Malate dehydrogenase-like enzyme MYLIP 6p23-p22.3 myosin regulatory light chain interacting protein MRPL42P2 6p22.3 myosin regulatory light chain interacting protein GMPR 6p23 guanosine monophosphate reductase SCA1 6p23 spinocerebellar ataxia 1 (olivopontocerebellar ataxia 1, autosomal dominant, ataxin 1) RNPC6 6p22.3 RNA-binding region (RNP1, RRM) containing 6 CAP2 6p22.3 CAP, adenylate cyclase-associated protein, 2 (yeast) FAM8A1 6p23 family with sequence similarity 8, member A1 NUP153 6p25.3-p22.1 nucleoporin 153kDa KIF13A 6p23 kinesin family member 13A NHLRC1 6p22.3 NHL repeat containing 1 TPMT 6p22.3 thiopurine S-methyltransferase AOF1 6p22.3 amine oxidase, flavin containing 1 DEK 6p23 DEK oncogene (DNA binding) LOC391872 6 similar to ATP-dependent RNA helicase DDX18 (DEAD-box protein 18) (Myc-regulated DEAD-box protein) (MrDb) LOC391873 6 similar to inosine monophosphate dehydrogenase 1 isoform b; sWSS2608 IBRDC2 6p22.3 IBR domain containing 2 LOC346129 6p22.3 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 3080 52.7 477 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart     Homo sapiens
Nervousbrain     Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier liningepidermis   Homo sapiens
Muscularstriatumskeletal   Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal fragment of CAP2 interacts with actin, indicating that CAP2 has the capacity to bind to actin
  • HOMOLOGY
    interspecies homolog to murine Cap2
    ortholog to rattus Cap2
    ortholog to murine 2810452G09Rik
    homolog to Drosophila capt
    homolog to C.elegans F41G4.2a
    intraspecies homolog to CAP1
    Homologene
    FAMILY
  • CAP family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • found in the nucleus in undifferentiated myoblasts and at the M-line of differentiated myotubes
  • enriched in the nucleus, and sparse in the cytosol
  • basic FUNCTION
  • involved in establishment and/or maintenance of cell polarity
  • having a regulatory bifunctional role
  • C-terminal fragment of CAP2 interacts with actin, indicating that CAP2 has the capacity to bind to actin
  • has the capacity to bind to actin
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text cell polarity
    PATHWAY
    metabolism
    signaling signal transduction
    cAMP pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to adenyl cyclase binding, CAP, actin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS