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FLASH GENE
Symbol CAND2 contributors: npt/ - updated : 27-03-2006
HGNC name cullin-associated and neddylation-dissociated 2 (putative)
HGNC id 30689
Location 3p25.2      Physical location : 12.838.170 - 12.876.313
Synonym name
  • TBP-interacting protein
  • cDNA sequence,expressed in brain,>100kDa,related to rat TIP120
  • cullin-associated NEDD8-dissociated protein 2
  • p120 CAND2
  • Synonym symbol(s) KIAA0667, TIP120B, Tp120b
    DNA
    TYPE functioning gene
    STRUCTURE 38.14 kb     13 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 4248 122.5 1119 - 2003 12692129
    15 - 4599 - 1236 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular     Homo sapiens
    Muscularstriatumskeletal specific Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminus of 209 AAs of TIP120B was responsible for the binding with CNOT3
  • HOMOLOGY
    interspecies homolog to rattus Tip120
    Homologene
    FAMILY
  • CAND family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • muscle-specific protein, and may have a specific role in muscle tissues, which may be diffrerent from that of CAND1
  • presumably affects tissue-specific transcriptional regulation via interaction with CNOT3
  • inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TBP (TATA-binding protein)
  • bind to cullin and negatively regulate SCF (Skp1-Cullin1-F-box protein) ubiquitin ligase
  • cell & other
    REGULATION
    induced by induced in association with myogenic differentiation
    Other regulated by UBE3C (may regulate CAND2 homeostasis specifically in skeletal muscle)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS