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FLASH GENE
Symbol CAMSAP3 contributors: mct/npt - updated : 30-08-2018
HGNC name calmodulin regulated spectrin associated protein family member 3
HGNC id 29307
Location 19p13.2      Physical location : -
Synonym name
  • hypothetical protein LOC57662
  • KIAA1543
  • protein phosphatase 1, regulatory subunit 80
  • Marshalin
  • Synonym symbol(s) KIAA1543, PPP1R80, NEZHA
    DNA
    TYPE functioning gene
    STRUCTURE 22.41 kb     19 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 4201 - 1276 - 2017 28089391
    17 - 4120 135 1249 - 2017 28089391
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestiveliver   highly
    Endocrinepancreas   highly
    Hearing/EquilibriumearinnercochleaCorti  Homo sapiens
    Nervousbrainbasal nucleicorpus callosum  
     braindiencephalonthalamus highly
     braindiencephalonhypothalamus highly
     brainbasal nucleicaudate nucleus highly
     brainhindbraincerebellum highly
     braindiencephalonamygdala highly
     spinal cord   lowly
    Reproductivefemale systemovary  highly
     male systemtestis  highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text highly in brain and liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal calponin homology domain
  • two central coiled-coil regions (CC1 and 2), and CC1 domain of CAMSAP3 is crucial for its apical localization
  • a C-terminal DUF1781 domain of unknown function
  • secondary structure
  • a short helical motif conserved in CAMSAP2 and CAMSAP3 binds to the heterodimer formed by the N- and C-terminal domains of katanin subunits p60 and p80, respectively
  • HOMOLOGY
    Homologene
    FAMILY
  • CAMSAP/Patronin family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • localized with PLEKHA7 along the zonula adherens (Meng 2008)
  • localizes at Noncentrosomal microtubules Minus Ends (Meng 2008)
  • non-centrosomal MT minus-end protein, accumulating in the pericentrosomal area and accompanies the release of MTs from the centrosome
  • basic FUNCTION
  • PLEKHA7/NEZHA complex regulates the zonula adherens integrity by recruiting KIFC3 to this junctional site (Meng 2008)
  • CAMSAP3 and its related protein, CAMSAP2, cooperate in organization of noncentrosomal microtubules
  • CAMSAP2 and -3 work together to maintain noncentrosomal microtubules, suppressing the microtubule-organizing ability of the centrosome, and that the network of CAMSAP-anchored microtubules is important for proper organelle assembly
  • members of the CAMSAP/Patronin family all localize to and protect minus-ends but have evolved distinct effects on MT dynamics
  • apically localized CAMSAP3 determines the proper orientation of microtubules, and in turn that of organelles, in mature mammalian epithelial cells
  • CAMSAP1, CAMSAP2, CAMSAP3 act to polarise microtubules (MT) along the apical-basal axis to enable apical transport of RAB11A endosomes
  • plays a role in translocation of Golgi vesicles in epithelial cells
  • is a key molecule for generation of non-centrosomal MTs
  • CAMSAP2 and CAMSAP3 bind to growing microtubule minus ends, where they form stretches of stabilized microtubule lattice
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • partner of PLEKHA7 (Meng 2008)
  • cooperates with KIFC3 for the maintenance of the zonula adherens (Meng 2008)
  • CAMSAP3-anchored non-centrosomal microtubules capture ARHGEF2 more efficiently than other microtubules do and a balance between these microtubules is important to maintain proper actin organization
  • interaction between CDH23 and CAMSAP3/Marshalin plays a vital role in hearing and vision, suggesting that CDH23-C is a CAMSAP3/Marshalin-binding protein that can modify MT networks indirectly through its interaction with CAMSAP3/Marshalin
  • MACF1 specifically binds to CAMSAP3 and is required for the apical localization of CAMSAP3-decorated microtubule minus ends
  • cell & other
  • bound microtubules at their minus ends and tethered them to the zonula adherens (Meng 2008)
  • CAMSAP1, CAMSAP2, CAMSAP3 bind specifically to MT minus-ends and protect them against kinesin-13-induced depolymerization
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS