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FLASH GENE
Symbol CAMKK1 contributors: mct - updated : 07-03-2012
HGNC name calcium/calmodulin-dependent protein kinase kinase 1, alpha
HGNC id 1469
Location 17p13.2      Physical location : 3.763.624 - 3.796.337
Synonym name
  • CAMKK alpha protein
  • CaM-kinase IV kinase
  • CaM-KK alpha
  • Synonym symbol(s) CAMKKA, MGC34095, DKFZp761M0423, CaM-KK 1
    EC.number 2.7.11.17
    DNA
    TYPE functioning gene
    STRUCTURE 32.73 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 splicing 3583 55.6 505 - 1999 10560916
    encoding the same protein than variant 2
    16 splicing 2535 57.4 520 - 1999 10560916
  • containing an additional segment in the coding region
  • using an alternate splice site in the 3' coding region that results in a frameshift compared to variant 1
  • 16 splicing 3529 55.6 505 - 1999 10560916
  • differing in the 5' UTR compared to variant 1
  • encoding the same protein than variant 1
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrinepancreas    
    Nervousbraindiencephalonamygdala highly Homo sapiens
     braindiencephalonhypothalamus highly Homo sapiens
     nervespinal nervesciatic  
    Reproductivefemale systemuteruscervix highly
     male systemprostate   
    Respiratorylung    
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Nervouscentral   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte Homo sapiens
    Endocrineislet cell (alpha,beta...)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a RP domain (arginine/proline-rich) involved in the recognition of CAMKI and CAMK4 as substrates
  • a protein kinase domain
  • an autoinhibitory domain overlapping with the calmodulin binding region and may be involved in intrasteric autoinhibition
  • HOMOLOGY
    interspecies homolog to rattus Camkk1 (93.7 pc)
    homolog to murine Camkk1 (93.5 pc)
    Homologene
    FAMILY
  • protein kinase superfamily
  • Ser/Thr protein kinase family
  • Ca(2+)/calmodulin-dependent protein kinase subfamily
  • belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • cytoplasmic localization of CAMKK1 depends on CRM1-mediated nuclear export mediated through a Rev-like nuclear export signal in the CAMKK1 regulatory domain
  • basic FUNCTION
  • playing a role in the calcium/calmodulin-dependent (CaM) kinase cascade
  • phosphorylating CAMK1, CAMK1D, CAMK1G and CAMK4
  • involved in regulating cell apoptosis
  • promoting cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death
  • stimulates glucose uptake via insulin-independent signaling mechanisms
  • implicated in the regulation of skeletal muscle glucose uptake independent of PRKAB1 and AKT1 activation
  • important new role for CAMKK1 in the differentiation of monocytic cells
  • capable of activating BRSK1 through phosphorylation of Thr (189)and CaMKK1 may be an alternative activating kinase for BRSK1
  • CAMKK1-induced phosphorylation of DNM1L regulates mitochondrial morphology (
  • act as regulatory enzymes for downstream protein kinases in various Ca2+-dependent cellular processes
  • mediates potentially novel Ca2+-signaling pathway(s), which are independent of downstream protein kinases
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • binding to ATP
  • protein
  • interacting with calmodulin
  • interacting with CAMK4
  • PACSIN1 is a CAMKK substrate (first non-kinase substrate for CAMKK1)
  • cell & other
    REGULATION
    activated by upregulated in an immediate early fashion during retinoic acid induced neutrophil maturation
    Ca(2+)/calmodulin
    Other partially inhibited upon phosphorylation by PRCAKA/PKA
    may be regulated through phosphorylation by CAMK1 and CAMK4
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS