Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CAMK4 contributors: mct - updated : 12-06-2013
HGNC name calcium/calmodulin-dependent protein kinase IV
HGNC id 1464
Location 5q22.1      Physical location : 110.560.081 - 110.820.746
Synonym name
  • CAM kinase IV
  • CAM kinase- GR
  • brain Ca++-calmodulin-dependent protein kinase type IV
  • CAM kinase- GR
  • Synonym symbol(s) CaMK-GR, MGC36771, CaMK IV, caMK
    EC.number 2.7.11.17
    DNA
    TYPE functioning gene
    STRUCTURE 260.80 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2272 - 473 - 2002 11951046
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus   highly
    Nervousbrainforebraincerebral cortex highly Homo sapiens
     nerve   highly
    Reproductivemale systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatum  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines EBV transformed B lymphoblastoid cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • on ATP binding region
  • a catalytic domain
  • a regulatory region composed of an autoinhibitory domain
  • a CaM binding domain
  • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • CAMK Ser/Thr protein kinase family
  • CaMK subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • phosphorylation of numerous synaptic substrates
  • potential modulator of B lymphocyte growth transformation
  • mediating contractile activity dependent gene regulation in muscle tissues and promoting mitochondrial biogenesis
  • is a signaling mechanism involved in the regulation of gene expression and dendrite growth
  • contributes to the diversity of dendrite arbors via restricted expression and regulation of distinct modes of dendrite elaboration
  • multifunctional serine/threonine protein kinase, which plays an important role in the spermatogenesis by phosphorylating protamines
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    text plasticity of glutamatergic synapses
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • CAMK4-CREBBP pathway is crucial for osteoclast differentiation and function, and regulate the transcriptional program of osteoclastic bone resorption
  • PLCB1/CAMK4-NFKB1 is involved in AGER mediated signaling pathway in human endothelial cells
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • calmodulin
  • interacting with CREBBP
  • TRPC6 promoted dendritic growth via the CAMK4-CREB pathway
  • HNRNPL is an essential component of CAMK4-regulated alternative splicing through CA repeats, with its phosphorylation likely playing a critical role
  • OGT modification participates in the regulation of CAMK4 activation and function, possibly coordinating nutritional signals with the immune and nervous systems (
  • mediates ionomycin-induced LIMK1 activation (
  • specifically binds to the C terminus of PHB2 and phosphorylates PHB2 at serine 91
  • regulates beta-cell proliferation and apoptosis in a CREB1-dependent manner and CAMK4-induced IRS2 expression is important in these processes
  • remarkably increased NOTCH1-IC stability, and the kinase activity of CAMK4 was essential for facilitating NOTCH1 signaling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in infertile men (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    osteoarticularbone 
    CAMK/CREBBP pathway is a therapeutic target for research into the treatment of various bone disease
    ANIMAL & CELL MODELS
  • decreased levels of Camk4 in the testis is a contributing factor to reduced fertility in male Crybb2-/- mice (