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FLASH GENE
Symbol CAMK2G contributors: mct - updated : 14-10-2011
HGNC name calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma
HGNC id 1463
Location 10q22.3      Physical location : 75.572.258 - 75.634.343
Synonym symbol(s) CAMK, CAMKG, CAMK-II, MGC26678
EC.number 2.7.1.123/ 2.7.11.17
DNA
TYPE functioning gene
STRUCTURE 62.09 kb     19 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
MRPS16 10q22.1 mitochondrial ribosomal protein S16 LOC118491 10q22.3 tetratricopeptide repeat-containing protein ANXA7 10q21.1-q21.2 annexin A7 ZMYND17 10q22.3 zinc finger, MYND domain containing 17 PPP3CB 10q22.3 protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta) C10orf29 MYOZ1 10q22.1 myozenin 1 SYNPO2L 10q22.3 synaptopodin 2-like LOC118704 10q22.3 similar to ARF GTPase-activating protein LOC389978 10 similar to Ribosome biogenesis protein BMS1 homolog GLUDP3 10q22.1 glutamate dehydrogenase pseudogene 3 SEC24C 10q22.3 SEC24 related gene family, member C (S. cerevisiae) FUT11 10q22.3 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) LOC118487 10q22.3 similar to RIKEN cDNA 1110001O19 LOC196752 10q22.3 similar to CG32542-PA KIAA0913 10q22.3 KIAA0913 protein NDST2 10q22 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 CAMK2G 10q22.3 calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma PLAU 10q23.3-q24.3 plasminogen activator, urokinase VCL 10q22.1-q23 vinculin AP3M1 10q22.3 adaptor-related protein complex 3, mu 1 subunit ADK 10q22.3 adenosine kinase
RNA
TRANSCRIPTS type messenger
text tissue specific distribution of isoforms
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 3818 - 556 - 2002 12032636
  • CAMK2G-A,CAMK2G I1
  • 20 - 3704 - 518 lymphoid, epithelial tissues 2002 12032636
  • variable region forming a large multimeric enzyme
  • CAMK2G-B,CAMK2G I3
  • 19 - 3635 - 495 lymphoid, epithelial tissues 2002 12032636
  • variable region
  • CAMK2G-C,CAMK2G I4
  • 21 - 3731 - 527 - 2002 12032636
  • CAMK2G-D,CAMK2G I2
  • - - 3751 - 411 - 2002 12032636
    - splicing 1000 - 239 - 1997 9240463
    transplicing including 3'end of SRP72
    - - 999 - - - 1997 9240463
    truncated form formed to the 3' end of SRP72
    20 - 3662 - 504 - 2002 12032636
  • CAMKG2 I6
  • 21 - 3767 - 539 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Nervousbraindiencephalonhypothalamus  
    Reproductivemale systemprostate   
    Respiratorylung    
    Visualeyeanterior segmentiris  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES globular
    STRUCTURE
    motifs/domains
  • a catalytic domain
  • a regulatory region composed of an autoinhibitory domain
  • a CaM binding domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,nucleus,nucleoplasm
    text post synaptic density
    basic FUNCTION
  • serine/threonine protein kinase,calcium/calmodulin dependent
  • phosphorylation of numerous synatic substrates including in channels,other signaling molecules and scaffolding proteins
  • role for CAMK in osteoclast differentiation and bone resorption
  • could serve as a unifying link between ER stress and the FAS and mitochondrial apoptotic pathways
  • critical regulator of multiple signaling networks regulating the proliferation of myeloid leukemia cells
  • molecular link translating intracellular calcium changes, which are intrinsically associated with glioma migration, to changes in CLCN3 conductance required for cell movement
  • PPP6C, and CAMK2G regulated apoptosis by controlling the expression level of CDKN1B
  • phosphorylating the CARD domain of BCL10, which regulates the interactions within the important CARD11, BCL10, MALT1 signalling complex
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    text plasticity of glutamate synapses
    PATHWAY
    metabolism organic acid
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specific interaction of ClCN3 and CAMK2G (in ClCN3-expressing cells, inhibition of CAMK2G reduced glioma invasion to the same extent as direct inhibition of CLCN3)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    iInhibiting CAMK2G may represent a novel approach in the targeted therapy of myeloid leukemia
    ANIMAL & CELL MODELS