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FLASH GENE
Symbol CAMK2B contributors: shn/npt/pgu - updated : 28-12-2017
HGNC name calcium/calmodulin-dependent protein kinase II beta
HGNC id 1461
Corresponding disease
MRD54 Mental retardation, autosomal dominant 54
Location 7p13      Physical location : 44.256.748 - 44.365.230
Synonym name
  • calcium/calmodulin-dependent protein kinase (CaM kinase) II beta
  • aM-kinase II beta chain
  • calcium/calmodulin-dependent protein kinase type II beta chain
  • CaM kinase II beta subunit
  • proline rich calmodulin-dependent protein kinase
    • Synonym symbol(s) CAM2, CAMK2, CAMKB, MGC29528, MRD54
    EC.number 2.7.11.17
    DNA
    TYPE functioning gene
    STRUCTURE 108.85 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - D7S2428 - D7S678 - CAMK2B - D7S2528 - D7S667 - cen
    RNA
    TRANSCRIPTS type messenger
    text 9 transcript variants encoding different isoforms have been identified
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 4025 - 479 - 2017 29100089
  • transcript variant 7
    • 20 - 4064 - 492 - 2017 29100089
  • transcript variant 6
    • 21 - 4214 - 542 - 2017 29100089
  • transcript variant 2
    • 24 - 4586 - 666 - 2017 29100089
    20 - 4139 - 517 - 2017 29100089
  • transcript variant 4
    • 19 - 4097 - 503 - 2017 29100089
  • transcript variant 5
    • 20 - 4142 - 518 - 2017 29100089
  • transcript variant 3
    • 16 - 3935 - 449 - 2017 29100089
  • transcript variant 8
    • 21 - 2427 - 542 - 2017 29100089
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbraincerebellum highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text fetal brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a catalytic domain
  • a regulatory region composed of an autoinhibitory domain
  • a calmodulin-binding domain
  • an ATP-binding site
  • autophosphorylation sites
    • HOMOLOGY
    interspecies ortholog to Camk2b, Mus musculus
    ortholog to Camk2b, Rattus norvegicus
    ortholog to camk2b1, Danio rerio
    Homologene
    FAMILY
  • serine/threonine protein kinase family
  • Ca(2+)/calmodulin-dependent protein kinase subfamily
    • CATEGORY enzyme , receptor membrane serine/threonine kinase
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,nucleus,nucleoplasm
    text insulin secretion vesicles
    basic FUNCTION
  • serine/threonine protein kinase, calcium/calmodulin dependent, controling insulin secretion
  • having important actions on proteins regulating cardiac excitation-contraction coupling
  • involved in synaptic plasticity in the brain, playing a dual role in excitatory synaptic plasticity: a signaling role during neuronal activity, and an actin-bundling role during the basal state in dendritic spines, thereby affecting both functional and structural plasticity of dendritic spines
  • phosphorylates MAP2, increasing its binding to microtubules
  • required for dendritic growth and branching
  • its activity regulates the proliferative potential of growth plate chondrocytes
  • CAMK2A, CAMK2B act in concert, but with distinct functions, to regulate hippocampal synaptic plasticity and learning
  • specifically activates IL10 promoter activity
  • distinct role in the induction of anergy in T lymphocytes, by differential regulation of IL10 and IL2 gene transcription suggesting MEF2A as a molecular target which can integrate different calcium signals
  • is critical for the proper morphological maturation of differentiating oligodendrocytes, an aspect of oligodendrocyte maturation that is mediated to a large extent by changes in the cellular cytoskeleton
  • critical role of CAMK2B in regulating oligodendrocyte maturation and CNS myelination via an actin-cytoskeleton-regulatory mechanism
    • . CAMK2A, CAMK2B are essential for various forms of synaptic plasticity
  • crucial role of CAMK2B in regulating CNS myelination, suggesting that a sodium-dependent glutamate transporter-CAMK2B-actin cytoskeleton axis plays an important role in the regulation of oligodendrocyte maturation and CNS myelination
  • molecular, temporal and region-specific role of CAMK2B in locomotion
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text growth control proliferation
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
  • cytoskeletal component in the postsynaptic structure
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • calcium/calmodulin-dependent protein kinase II inhibitor 2 (CAMK2N2)
  • leucine rich repeat containing 7 (LRRC7 also known as Densin-180)
  • CAMK2B robustly phosphorylates the intracellular domain of NLGN1
  • CAMK2B protects neurons from Homocysteine-induced apoptosis with the involvement of HIF1A signal pathway
  • PLAA is located in caveolae, where it interacts with PDIA3 and CAV1 to initiate rapid signaling via CAMK2A, CAMK2B
    • cell & other
    REGULATION
    repressed by WNT signaling and PTHLH-induced phosphatase activity which negatively regulate CAMK2 activity
    ASSOCIATED DISORDERS
    corresponding disease(s) MRD54
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in cardiomyopathy
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Camk2b(-/-) mice, which lack the beta isoform of Calcium/Calmodulin-dependent protein kinase 2 (CAMK2B), show very severe locomotion deficits