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FLASH GENE
Symbol CAMK1 contributors: mct - updated : 10-05-2011
HGNC name calcium/calmodulin-dependent protein kinase I
HGNC id 1459
Location 3p25.2      Physical location : 9.799.032 - 9.811.661
Synonym symbol(s) MGC120317, MGC120318
EC.number 2.7.1.123
DNA
TYPE functioning gene
STRUCTURE 12.63 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 1501 - 370 - 1995 7641687
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
Lymphoid/Immunelymph node   highly
Nervousgangliasensory gangliadorsal root  
 nerve   highly
Reproductivefemale systemovary   
 male systemprostate   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Connectivebone  highly
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneB cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • central autoinhibitory domain (AA 295-306)
  • C terminal Ca-M binding domain
  • mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY SER/THR family of protein kinase,CAMK subfamily
    CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • phosphorylating synapsin 1
  • involved in a number of cellular processes like transcriptional regulation, hormone production, translational regulation, regulation of actin filament organization and neurite outgrowth
  • involved in calcium- dependent activation of the ERK pathway
  • potentially implicated in the regulation of bone and cartilage development
  • can regulates the functions of RPS19 through phosphorylation of Ser59
  • recruiting Ca(2+)-permeable AMPARs which may provide a mechanistic link between NMDAR activation in long-term potentiation and regulation of a signaling pathway that drives spine enlargement via actin polymerization (
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NR4A1 is a mediator of cAMP action on STAR transcription in steroidogenic Leydig cells through interaction with CAMK1
  • Calcium-calmodulin kinase I (CAMK1) cooperatively regulates nucleocytoplasmic shuttling of PCYT1A by accessing a nuclear export signal
  • cell & other
    REGULATION
    activated by calcium/calmodulin CAMKK2
    Other phosphorylation at threonine-177 by CAMK1 kinase
    YWHAH (directly regulate CAMK1 when the enzyme is phosphorylated by protein kinase A on either Ser74 or Ser475)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS