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FLASH GENE
Symbol CALY contributors: mct - updated : 13-01-2015
HGNC name calcyon neuron-specific vesicular protein
HGNC id 17938
Location 10q26.3      Physical location : 135.138.927 - 135.150.475
Synonym name
  • D1 dopamine receptor-interacting protein
  • dopamine receptor D1 interacting protein
  • calcyon protein
  • Synonym symbol(s) DRD1IP, CALCYON, RP11-122K13.5, NSG3
    DNA
    TYPE functioning gene
    STRUCTURE 11.55 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 983 23 217 - 2006 16595675
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary   
    Nervousbrainbasal nucleistriatum highly Homo sapiens
     brainlimbic systemhippocampus highly Homo sapiens
     braindiencephalonthalamusnucleipredominantly Homo sapiens
     brainforebraincerebral cortexfrontal cortex  Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...)
    Nervousastrocyte Homo sapiens
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text fetal eyes, lens, eye anterior segment, optic nerve, retina, retina foveal and macular, RPE and choroid
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • NEEP21 family
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • type III membrane protein
  • localized to vesicular compartments within pre- and postsynaptic structures
  • basic FUNCTION
  • required for maximal stimulated calcium release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors
  • role for calcyon in clathrin-mediated endocytosis in brain
  • may have a role in potentiating calcium ion-dependent signaling
  • brain-specific D1-interacting protein involved in D1/D5 receptors calcium signaling
  • mobility and storage properties of calcyon-containing vesicles imply that they play a role in brain plasticity
  • endocytic protein that regulates clathrin assembly and clathrin-mediated endocytosis in the brain
  • plays potentially a specialized role in regulating activity-dependent removal of synaptic AMPARs
  • NSG1 and CALY play related, but distinct roles in regulating vesicle trafficking at synapses, and in neurons in general
  • neural enriched, single transmembrane protein that interacts with clathrin light chain and stimulates clathrin assembly and clathrin-mediated endocytosis
  • stimulates clathrin-mediated endocytosis and endosomal targeting
  • NSG1 and CALY perform distinct roles in regulating receptor endocytosis, recycling, and degradation
  • balancing NSG1 and CALY expression and/or activity could be important for homeostasis in a variety of signaling pathways, and also lead to a novel therapeutic strategy for disorders like Alzheimer disease and schizophrenia
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with D1 dopamine receptor and may interact with other DA receptor subtypes and/or GPCRs
  • regulates the subcellular distribution of AP3 adaptor protein and the targeting of AP3 cargoes
  • interacting directly with DRD1, and is implicated in various neuropsychiatric disorders including schizophrenia, bipolar disorder, and attention deficit hyperactivity disorder
  • interacts with DLG4 and subsequently forms a ternary complex with DRD1 through DLG4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to deficit/hyperactivity disorder (ADHD)
    Variant & Polymorphism other haplotype C1 containing a risk allele for deficit/hyperactivity disorder
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS