basic FUNCTION
| required for maximal stimulated calcium release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors |
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role for calcyon in clathrin-mediated endocytosis in brain |
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may have a role in potentiating calcium ion-dependent signaling |
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brain-specific D1-interacting protein involved in D1/D5 receptors calcium signaling |
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mobility and storage properties of calcyon-containing vesicles imply that they play a role in brain plasticity |
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endocytic protein that regulates clathrin assembly and clathrin-mediated endocytosis in the brain |
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plays potentially a specialized role in regulating activity-dependent removal of synaptic AMPARs |
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NSG1 and CALY play related, but distinct roles in regulating vesicle trafficking at synapses, and in neurons in general |
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neural enriched, single transmembrane protein that interacts with clathrin light chain and stimulates clathrin assembly and clathrin-mediated endocytosis |
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stimulates clathrin-mediated endocytosis and endosomal targeting |
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NSG1 and CALY perform distinct roles in regulating receptor endocytosis, recycling, and degradation |
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balancing NSG1 and CALY expression and/or activity could be important for homeostasis in a variety of signaling pathways, and also lead to a novel therapeutic strategy for disorders like Alzheimer disease and schizophrenia |