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FLASH GENE
Symbol CALU contributors: mct - updated : 04-03-2019
HGNC name calumenin
HGNC id 1458
Location 7q32.1      Physical location : 128.379.345 - 128.411.530
Synonym name
  • crocalbin-like protein
  • Synonym symbol(s) FLJ90608
    DNA
    TYPE functioning gene
    STRUCTURE 34.13 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    PAX4 7q32 paired box gene 4 SND1 7q31.3 paired box gene 4 NSG-X 7q31 brain and nasopharyngeal carcinoma susceptibility protein LRRC4 7q31 leucine rich repeat containing 4 LEP 7q31.3 leptin (obesity homolog, mouse) MGC27345 7q32.2 hypothetical protein MGC27345 FLJ10377 7q32.2 hypothetical protein FLJ10377 LOC389551 7 hypothetical gene supported by BC063892 IMPDH1 7q31.3-q32 IMP (inosine monophosphate) dehydrogenase 1 HIG2 7q32.2 hypoxia-inducible protein 2 METTL2 17q24.1 methyltransferase like 2 LOC389552 7 similar to Serine/threonine-protein kinase tousled-like 2 (Tousled-like kinase 2) (PKU-alpha) LOC389553 7 hypothetical gene supported by AL137733 LOC389554 7 hypothetical gene supported by BC062355 LOC392095 7 similar to capicua homolog LOC346653 7q32.2 hypothetical protein LOC346653 NYD-SP18 7q32.2-q32.3 testes development-related NYD-SP18 CALU 7q32 calumenin OPN1SW 7q31.3-q32 opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan) DKFZP434G156 7q33 hypothetical protein DKFZp434G156 FLNC 7q32 filamin C, gamma (actin binding protein 280) ATP6V1F 7q32 ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F LOC389555 7 similar to Filamin C (Gamma-filamin) (Filamin 2) (Protein FLNc) (Actin-binding like protein) (ABP-L) (ABP-280-like protein) IRF5 7q32 interferon regulatory factor 5 TNPO3 7q32.3 transportin 3 LOC392096 7 similar to Triosephosphate isomerase (TIM) HCP20 7q32.3 cytochrome c, somatic pseudogene LOC286017 7q32.3 similar to mitogen-activated protein kinase kinase 2; mitogen-activated protein kinase kinase 2, p45; MAP kinase kinase 2; MAPK/ERK kinase 2; dual specificity mitogen-activated protein kinase kinase 2; ERK activator kinase 2 MGC50844 7q32.3 hypothetical protein MGC50844 LOC154981 7q32.3 hypothetical LOC154981 SMO 7q31 smoothened homolog (Drosophila) KIAA0828 7q32.3 KIAA0828 protein KIAA1170 7q32.3 KIAA1170 protein NRF1 7q32 nuclear respiratory factor 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 6181 - 323 - 1999 10222138
    8 - 6181 - 323 - 1999 10222138
    7 - 5366 - 315 - 1999 10222138
    6 - 5166 - 224 - 1999 10222138
    7 - 5366 - 315 - 1999 10222138
    5 - 4940 - 164 - 1999 10222138
    - - - - - shuttles between the nucleus and cytoplasm through interacting with importin alpha, Ran GTPase, and CRM1 2013 24136234
  • promotes filopodia formation and cell migration
  • in the nucleus, CALU-15 increases the transcription of growth differentiation factor-15 (GDF15) (PMID: 24136234)
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly Homo sapiensFetal
    Nervousbrainlimbic systemhippocampusdentate gyrus  Homo sapiensFetal
    Skin/Tegumentskin   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Connectivebone  highly
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticplatelet Homo sapiens
    Nervousglia Homo sapiensFetal
    Nervousneuron Homo sapiensFetal
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six EF-hand domains
  • potential N-glycosylation site
  • at the C terminus a HDEF sequence, retrieval signal and an ER retention signal
  • HOMOLOGY
    interspecies homolog to murine Calu
    Homologene
    FAMILY CREC family of Ca2+-binding proteins having multiple EF-hands
    CATEGORY chaperone/stress , transport
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text demonstrated in the ER as well as in the Golgi complex
    basic FUNCTION
  • calumenin CA++ binding proteins in the ER and Golgi apparatus
  • involved in such ER functions as protein folding and sorting
  • may participate in the immunological defense system and could be involved in the pathological process of amyloidosis that leads to formation of amyloid deposits seen in different types of tissues
  • may have an autocrine or a paracrine effect on the cells in its vicinity, and, therefore, may be involved in the pathophysiology of thrombosis or in wound healing (
  • influence the synthesis of certain coagulation factors
  • may be broadly involved in haemostasis and in the pathophysiology of thrombosis
  • potential novel regulator of ATP2A2, and its expressional changes are tightly coupled with Ca(2+)-cycling of cardiomyocytes
  • possible important role of CALU in migration and differentiation of neurons, and/or in Ca(2+) signaling between glial cells and neuron
  • extracellular calumenin as a suppressor of cell migration and tumor metastasis
  • calumenin regulates FBLN1 to have crucial roles in ERK1/2 signaling and cell migration
  • is a Ca2+ sensor, which folds into a compact structure, capable of interacting with its molecular partners, when Ca2+ concentration within the ER reaches the millimolar range
  • multi-EF-hand-containing Ca2+-binding protein
  • is intrinsically unstructured in the Ca2+ free form and responds to Ca2+ with a dramatic gain in structure
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TSP1 (in the presence of Ca(2+) binds to TSP1)
  • interacts with RYR2 and ATP2A2, and therefore changes in the expression of calumenin could potentially alter Ca2+ cycling in heart
  • CALU binds to and stabilizes FBLN1, leading to inactivation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) signaling
  • MMP13 proteolyzes FBLN1 and CALU protects FBLN1 from cleavage by MMP13
  • CALU inhibits gamma-carboxylation of MGP preventing BMP2-dependent calcification
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    respiratoryCF (mucoviscidosis) 
    modulation of CALU expression or activity may be used as a potential therapeutic tool to correct defects in F508del-CFTR
    ANIMAL & CELL MODELS