| basic FUNCTION
| calumenin CA++ binding proteins in the ER and Golgi apparatus |
|
involved in such ER functions as protein folding and sorting |
|
may participate in the immunological defense system and could be involved in the pathological process of amyloidosis that leads to formation of amyloid deposits seen in different types of tissues |
|
may have an autocrine or a paracrine effect on the cells in its vicinity, and, therefore, may be involved in the pathophysiology of thrombosis or in wound healing ( |
|
 |
|
influence the synthesis of certain coagulation factors |
|
may be broadly involved in haemostasis and in the pathophysiology of thrombosis |
|
potential novel regulator of ATP2A2, and its expressional changes are tightly coupled with Ca(2+)-cycling of cardiomyocytes |
|
possible important role of CALU in migration and differentiation of neurons, and/or in Ca(2+) signaling between glial cells and neuron |
|
extracellular calumenin as a suppressor of cell migration and tumor metastasis |
|
calumenin regulates FBLN1 to have crucial roles in ERK1/2 signaling and cell migration |
|
is a Ca2+ sensor, which folds into a compact structure, capable of interacting with its molecular partners, when Ca2+ concentration within the ER reaches the millimolar range |
|
multi-EF-hand-containing Ca2+-binding protein |
|
is intrinsically unstructured in the Ca2+ free form and responds to Ca2+ with a dramatic gain in structure |
