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FLASH GENE
Symbol CALR3 contributors: mct/npt - updated : 10-12-2013
HGNC name calreticulin 3
HGNC id 20407
Corresponding disease
Location 19p13.11      Physical location : 16.589.874 - 16.607.003
Synonym name
  • calreticulin
  • calreticulin 2
  • cancer/testis antigen 93
  • calsperin
  • Synonym symbol(s) CRT2, FLJ25355, MGC26577, CT93, CMH19
    DNA
    TYPE functioning gene
    STRUCTURE 17.13 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    OR10H2 19p13.1 olfactory receptor, family 10, subfamily H, member 2 OR10H3 19p13.1 olfactory receptor, family 10, subfamily H, member 3 LOC388514 19 similar to Cytochrome P450 4F12 (CYPIVF12) LOC284433 19p13.12 hypothetical gene supported by NM_013940 OR10H1 19p13.1 olfactory receptor, family 10, subfamily H, member 1 LOC388515 19 LOC388515 LOC339377 19p13.12 similar to 4930572L20Rik protein CYP4F2 19p13.1-p12 cytochrome P450, family 4, subfamily F, polypeptide 2 CYP4F11 19p13.1 cytochrome P450, family 4, subfamily F, polypeptide 11 LOC126541 19p13.12 similar to Olfactory receptor 10H4 LOC126537 19p13.12 similar to cytochrome P-450 FLJ25328 19p13.12 hypothetical protein FLJ25328 TPM4 19p13.1 tropomyosin 4 MEL 19p13.1 mel transforming oncogene (derived from cell line NK14)- RAB8 homolog HSH2 19p13.12 mel transforming oncogene (derived from cell line NK14)- RAB8 homolog KIP3 DKFZP586O0120 AP1M1 19p13.2 adaptor-related protein complex 1, mu 1 subunit KLF2 19p13.13-p13.11 Kruppel-like factor 2 (lung) EPS15R 19p13.12 Kruppel-like factor 2 (lung) CALR3 19p13.11 calreticulin 3 FLJ21742 19p13.12 hypothetical protein FLJ21742 CHERP 19p13.1 calcium homeostasis endoplasmic reticulum protein SLC35E1 19p13.12 solute carrier family 35, member E1 CRSP7 19p13.12 cofactor required for Sp1 transcriptional activation, subunit 7, 70kDa MGC2747 19p13.12 hypothetical protein MGC2747 MGC3169 19p13.12 hypothetical protein MGC3169 LOC284434 19p13.12 hypothetical protein LOC284434 SIN3B 19p13.11 SIN3 homolog B, transcriptional regulator (yeast) F2RL3 19p12 coagulation factor II (thrombin) receptor-like 3 VIP 6q24-q27 vasoactive intestinal peptide MGC20533 19p13.12 similar to RIKEN cDNA 2410004L22 gene (M. musculus) MYO9B 19p13.1 myosin IXB
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1285 - 384 - 2007 17975137
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivegerm cell Homo sapiens
    Reproductivespermatid
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Calr3
    intraspecies homolog to testis-specific homologs of CALR
    Homologene
    FAMILY
  • calreticulin family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • endoplasmic and sarcoplasmic reticulum
  • CLGN is membrane-anchored whereas CALR3 is soluble
  • basic FUNCTION
  • calcium ion storage activity
  • lectin-deficient chaperone directly required for ADAM3A maturation
  • testis-specific calreticulin homologs CLGN and CALR3 have distinct but cooperative roles in the maturation of ADAM3A during spermatogenesis and subsequent sperm fertilizing ability
  • CELLULAR PROCESS protein, post translation
    protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly associates with ADAM3A and controls its maturation
  • PDILT cooperates with CALR3, in the endoplasmic reticulum and plays an indispensable role in the disulfide-bond formation and folding of ADAM3A
  • recognizes ADAM3A with the aid of PDILT and the complex promotes ADAM3A maturation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CMH19
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cancer tissues (particularly melanoma)(Hayashi 2007)
    Susceptibility to familial hypertrophic cardiomyopathy (Chiu 2007)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    reproductioncontraception 
    manipulation of the testis-specific CLGN/CALR3 ER quality control system could be exploited to develop novel therapeutic approaches for contraception
    reproductionfertility 
    manipulation of the testis-specific CLGN/CALR3 ER quality control system could be exploited to develop novel therapeutic approaches for treatment of male infertility
    ANIMAL & CELL MODELS
  • murine Calr3(-/-) males produced apparently normal sperm but were infertile because of defective sperm migration from the uterus into the oviduct and defective binding to the zona pellucida