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FLASH GENE
Symbol CALR3 contributors: mct/npt - updated : 10-12-2013
HGNC name calreticulin 3
HGNC id 20407
Corresponding disease
Location 19p13.11      Physical location : 16.589.874 - 16.607.003
Synonym name
  • calreticulin
  • calreticulin 2
  • cancer/testis antigen 93
  • calsperin
    • Synonym symbol(s) CRT2, FLJ25355, MGC26577, CT93, CMH19
    DNA
    TYPE functioning gene
    STRUCTURE 17.13 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1285 - 384 - 2007 17975137
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivegerm cell Homo sapiens
    Reproductivespermatid
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Calr3
    intraspecies homolog to testis-specific homologs of CALR
    Homologene
    FAMILY
  • calreticulin family
    • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • endoplasmic and sarcoplasmic reticulum
  • CLGN is membrane-anchored whereas CALR3 is soluble
    • basic FUNCTION
  • calcium ion storage activity
  • lectin-deficient chaperone directly required for ADAM3A maturation
  • testis-specific calreticulin homologs CLGN and CALR3 have distinct but cooperative roles in the maturation of ADAM3A during spermatogenesis and subsequent sperm fertilizing ability
    • CELLULAR PROCESS protein, post translation
    protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly associates with ADAM3A and controls its maturation
  • PDILT cooperates with CALR3, in the endoplasmic reticulum and plays an indispensable role in the disulfide-bond formation and folding of ADAM3A
  • recognizes ADAM3A with the aid of PDILT and the complex promotes ADAM3A maturation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CMH19
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cancer tissues (particularly melanoma)(Hayashi 2007)
    Susceptibility to familial hypertrophic cardiomyopathy (Chiu 2007)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    reproductioncontraception 
    manipulation of the testis-specific CLGN/CALR3 ER quality control system could be exploited to develop novel therapeutic approaches for contraception
    reproductionfertility 
    manipulation of the testis-specific CLGN/CALR3 ER quality control system could be exploited to develop novel therapeutic approaches for treatment of male infertility
    ANIMAL & CELL MODELS
  • murine Calr3(-/-) males produced apparently normal sperm but were infertile because of defective sperm migration from the uterus into the oviduct and defective binding to the zona pellucida