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FLASH GENE
Symbol CALML3 contributors: mct - updated : 26-04-2017
HGNC name calmodulin-like 3
HGNC id 1452
Location 10p15.1      Physical location : 5.566.923 - 5.568.225
Synonym symbol(s) CLP
DNA
TYPE like-sequence
STRUCTURE 1.38 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned   linked N status provisional
Physical map
COPEB 10p15 core promoter element binding protein LOC387632 10 LOC387632 AKR1CL2 10p15.2 aldo-keto reductase family 1, member C-like 2 LOC389932 10 similar to 3-hydroxyhexobarbital dehydrogenase 1/3-alpha, 17-beta-hydroxysteroid dehydrogenase AKR1C1 10p15-p14 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) AKR1C2 10p15-p14 aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III) AKR1C3 10p15-p14 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) LOC389933 10 similar to 3(20)alpha-hydroxysteroid/dihydrodiol dehydrogenase LOC340811 10p15.2 protein RAKc AKR1C4 10p15-p14 aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4) LOC389934 10 similar to protein RAKc UCN3 10p15.1 urocortin 3 (stresscopin) FLJ21665 10p15.1 hypothetical protein FLJ21665 NET1 10p15 neuroepithelial cell transforming gene 1 CALML5 10p15.1 calmodulin-like 5 CALML3 10pter-p13 calmodulin-like 3 ASB13 10p15.1 ankyrin repeat and SOCS box-containing 13 FLJ20360 10p15.1 hypothetical protein FLJ20360 GDI2 10p15 GDP dissociation inhibitor 2 ANKRD16 10p15.1 ankyrin repeat domain 16 FBXO18 10p15.1 F-box only protein, helicase, 18 IL15RA 10p15-p14 interleukin 15 receptor, alpha IL2RA 10p15-p14 interleukin 2 receptor, alpha SPF45 LOC387633 10 LOC387633 LOC142937 10p15.1 hypothetical protein BC008131 PFKFB3 10p15-p14 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 PRKCQ 10p15 protein kinase C, theta SFMBT2 10p15.1 Scm-related gene containing four mbt domains 2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 1417 - 149 - 2009 18818677
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly Homo sapiens
Reproductivefemale systembreastmammary gland  
 female systemuteruscervix  
 male systemprostate   
Respiratoryrespiratory tractlarynx  highly
Skin/Tegumentskin   highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier lining    Homo sapiens
Epithelialbarrier liningepidermisstratum granulosum  Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveepithelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
four EF-hand domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme , regulatory
SUBCELLULAR LOCALIZATION extracellular
basic FUNCTION
  • may be similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinities, to cellular substrates
  • CALML3 functions to increase translation of MYO10 possibly by acting as a chaperone for the emerging MYO10 heavy chain protein
  • epithelial-specific Ca(2+)-binding protein that is regulated during terminal keratinocyte differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    four calcium ions
    protein
  • phenylalanine-795 in the third IQ domain (IQ3) of MYO10 is critical for CALML3 binding
  • increased CALML3 expression and CALML3-mediated MYO10 function are important for skin differentiation and wound reepithelialization
  • when co-expressed in oocytes, CALML3 rendered KCNQ1 channels resistant to the voltage-dependent depletion of phosphatidylinositol 4,5-bisphosphate by voltage-sensitive phosphatase
  • cell & other
    REGULATION
    induced by beta type transforming growth factor
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • could be used as marker for the various phases of oral tumor progression in oral cancer
  • useful marker for normal and benign hyperplastic epidermal development, whereas the loss of nuclear CALML3 indicates progression to a proliferative and potentially malignant phenotype
  • Therapy target
    ANIMAL & CELL MODELS