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FLASH GENE

Symbol

CALML3

contributors: mct - updated : 26-04-2017

HGNC name	calmodulin-like 3
HGNC id	1452

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	10p15.1      Physical location : 5.566.923 - 5.568.225
Synonym symbol(s)	CLP

DNA

TYPE	like-sequence
STRUCTURE	1.38 kb     1 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005185 1 - 1417 NP_005176 - 149 - 2009 18818677

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth       highly Homo sapiens Reproductive female system breast mammary gland       female system uterus cervix       male system prostate       Respiratory respiratory tract larynx     highly Skin/Tegument skin       highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier lining       Homo sapiens Epithelial barrier lining epidermis stratum granulosum   Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Digestive epithelial cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

four EF-hand domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	may be similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinities, to cellular substrates
	CALML3 functions to increase translation of MYO10 possibly by acting as a chaperone for the emerging MYO10 heavy chain protein
	epithelial-specific Ca(2+)-binding protein that is regulated during terminal keratinocyte differentiation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	four calcium ions

protein	phenylalanine-795 in the third IQ domain (IQ3) of MYO10 is critical for CALML3 binding
	increased CALML3 expression and CALML3-mediated MYO10 function are important for skin differentiation and wound reepithelialization
	when co-expressed in oocytes, CALML3 rendered KCNQ1 channels resistant to the voltage-dependent depletion of phosphatidylinositol 4,5-bisphosphate by voltage-sensitive phosphatase

cell & other

REGULATION

induced by

beta type transforming growth factor

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	could be used as marker for the various phases of oral tumor progression in oral cancer
	useful marker for normal and benign hyperplastic epidermal development, whereas the loss of nuclear CALML3 indicates progression to a proliferative and potentially malignant phenotype
Therapy target

ANIMAL & CELL MODELS