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FLASH GENE
Symbol CALCRL contributors: mct - updated : 20-12-2014
HGNC name calcitonin receptor-like
HGNC id 16709
Location 2q32.1      Physical location : 188.207.850 - 188.313.021
Synonym name
  • calcitonin gene-related peptide type 1 receptor
  • calcitonin receptor-like receptor
  • Synonym symbol(s) CRLR, CGRPR, CLR
    DNA
    TYPE functioning gene
    STRUCTURE 105.33 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 6155 52 461 - 2007 17785463
    14 - 5990 - 461 heart, lung, kidney 2007 17785463
    - - 3400 - 461 - 2007 17785463
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   predominantly
    Digestiveintestinelarge intestinecolon   Homo sapiensmRNA
     intestinesmall intestineileum   Homo sapiensmRNA
     stomach     Homo sapiensmRNA
    Nervousbrainhindbraincerebellum   Rattus norvegicus
    Respiratorylung     Homo sapiensFetal
     respiratory tracttrachea  predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow    Mus musculus
    Muscularstriatumskeletal highly Rattus norvegicus
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage Mus musculus
    NervousPurkinje cell Rattus norvegicus
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal-CALCRL is structured and further a significant part of the binding affinity comes from binding to the N terminal-domain
  • C-tail is crucial for ADM-evoked cAMP production and internalization of the CALCRL/RAMP2
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Calcrl
    Homologene
    FAMILY G protein-coupled receptor family 2
    CATEGORY signaling hormone , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • can engage signaling partners, such as G proteins and beta-arrestin, following CGRP stimulation, only in the presence of RAMP1
  • requires coexpression of different receptor activity modifying proteins (RAMP) to become a functional calcitonin gene-related peptide (CGRP) receptor or an adrenomedullin (AM) receptor
  • acts as a receptor for the calcitonin gene-related peptide (CALCA) but in order to recognize CALCA, it must form a complex with an accessory protein, receptor activity modifying protein 1 (RAMP1)
  • CALCRL is an important factor in aging and associated disorders
  • ADM receptor components CALCRL and RAMP2 gene expression increased with increasing gestational age
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
  • functional CGRP receptors result from the association of a homo-oligomer of the calcitonin receptor-like receptor with a monomer of the accessory protein receptor activity-modifying protein-1 (RAMP1)
  • forms a heterodimer with receptor activity-modifying protein 2 (RAMP2)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RCP9
  • interacting with RAMP1 (requires the assembly of the seven-transmembrane domain calcitonin receptor-like receptor with the single-transmembrane domain receptor activity-modifying prtein-1 to reach the cell surface and be active)
  • TNFSF11 induces the formation of receptors for calcitonin (CALCRL)and CALCA in the bone marrow macrophages (BMM)3)
  • with RAMP2 serves as the adrenomedullin (AM) receptor to control neovascularization
  • CALCA exerts its diverse effects on vasodilation, nociception, secretion, and motor function through a heterodimeric receptor comprising of CALCRL and receptor activity-modifying protein 1 (RAMP1)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in clear cell renal cell carcinoma, in advanced stages, correlated with high tumor grade and conferred shorter overall survival
    Susceptibility
  • to essential hypertension
  • to gestational diabetes (GDM)
  • Variant & Polymorphism SNP
  • 8SNP
  • two CALCRL variants were associated with gestational diabetes (GDM) risk
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerurinary 
    target for future functional studies and drug development in clear cell renal cell carcinoma
    ANIMAL & CELL MODELS