SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
| intracellular,cytoplasm,organelle,endosome
|
| intracellular,cytoplasm,organelle,lysosome
|
basic FUNCTION
| can engage signaling partners, such as G proteins and beta-arrestin, following CGRP stimulation, only in the presence of RAMP1 |
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requires coexpression of different receptor activity modifying proteins (RAMP) to become a functional calcitonin gene-related peptide (CGRP) receptor or an adrenomedullin (AM) receptor |
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acts as a receptor for the calcitonin gene-related peptide (CALCA) but in order to recognize CALCA, it must form a complex with an accessory protein, receptor activity modifying protein 1 (RAMP1) |
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CALCRL is an important factor in aging and associated disorders |
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ADM receptor components CALCRL and RAMP2 gene expression increased with increasing gestational age |