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FLASH GENE
Symbol CALCOCO2 contributors: mct/npt - updated : 30-10-2017
HGNC name calcium binding and coiled-coil domain 2
HGNC id 29912
Location 17q21.32      Physical location : 46.908.371 - 46.942.228
Synonym name
  • nuclear dot protein 52
  • nuclear domain protein 52
  • nuclear domain 10 protein NDP52
  • Synonym symbol(s) NDP52, MGC17318
    DNA
    TYPE functioning gene
    STRUCTURE 34.26 kb     13 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 3299 - 446 - 2015 26506893
    14 - 3754 - 470 - 2015 26506893
    12 - 3556 - 404 - 2015 26506893
    12 - 3492 - 374 - 2015 26506893
    - - 3745 - 467 - 2015 26506893
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal SKICH domain of unknown structure (AA 1127),
  • an extended central coiled coil domain containing a leucine zipper motif (AA 140420)
  • a C2H2-type zinc finger structure and this zinc finger in complex with mono-ubiquitin uncovers a unique zinc finger-binding mode for ubiquitin
  • a noncanonical LIR motif providing specificity for MAP1LC3C
  • a LIM-like C terminal domain
  • myosin tail
  • mutiple phosphorylation sites
  • a C-terminal ubiquitin-binding Zn finger domain (ZnF, AA 421446)
  • HOMOLOGY
    intraspecies paralog to MAVS
    Homologene
    FAMILY
    CATEGORY protooncogene , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus,nucleoplasm,nuclear bodies,PML
    intracellular,nuclear envelope
    text
  • expressed in the nuclear domain (ND) 10 (POD (PML) promyelocytic oncogenic domain or Kr bodies
  • with TAX1BP1 and myosin VI are present at the trans side of the Golgi complex, and on vesicles in the perinuclear region (Morriswood 2007)
  • basic FUNCTION
  • polyubiquitin binding protein involved in NF-kappaB signaling (Fenner 2009)
  • SQSTM1 and CALCOCO2 act cooperatively to drive efficient antibacterial autophagy by targeting the protein complexes they coordinate to distinct micro-domains associated with bacteria
  • plays a role as an autophagic receptor for phosphorylated tau facilitating its clearance via autophagy
  • autophagy receptor CALCOCO2 plays a dual function during xenophagy first by targeting bacteria to nascent autophagosomes and then by promoting autophagosome maturation in order to destroy bacteria
  • functions as a bridging adaptor and plays an essential role in the selective autophagic degradation of invading pathogens by specifically recognizing ubiquitin-coated intracellular pathogens and subsequently targeting them to the autophagic machinery
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with HCAP1
  • myosin VI binding partner (Morriswood 2007)
  • by recruiting CALCOCO2, LGALS8 activates antibacterial autophagy
  • is a key autophagy receptor for phosphorylated MAPT in brain
  • TBK1 kinase addiction in lung cancer cells is mediated via autophagy of TAX1BP1/CALCOCO2 and non-canonical NFKB1 signalling
  • considerable interaction between TRIM31 and CALCOCO2
  • RAB35 accumulates on bacteria-containing endosomes, and RAB35 directly binds and recruits CALCOCO2 to internalized bacteria
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS