motifs/domains
| N terminus containing an activation domain, which is necessary and sufficient for synergistic activation of LEF1-mediated transcription by CALCOCO1 and beta-catenin, and EP300 binding motif, which is important for synergistic cooperation with EP300 as coactivators for LEF1 and beta-catenin |
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a rodlike tail sequence highly repetitive, composed of an heptapeptide repeat pattern characteristic of alpha-helical coiled coils |
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C-terminal activation domain (AD) is used for downstream signaling, possesses strong transactivation activity and is required for the coactivator function of CALCOCO1 with nuclear receptor |