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FLASH GENE
Symbol CALCOCO1 contributors: mct - updated : 24-03-2011
HGNC name calcium binding and coiled-coil domain 1
HGNC id 29306
Location 12q13.13      Physical location : 54.104.902 - 54.121.307
Genatlas name calphoglin
Synonym name
  • KIAA1536 protein
  • coiled-coil coactivator
  • Synonym symbol(s) PP13275, calphoglin, KIAA1536, Cocoa
    DNA
    TYPE functioning gene
    STRUCTURE 16.40 kb     15 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 3046 - 691 - 2004 15522220
    14 - 2790 - 606 - 2004 15522220
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   moderately
    Nervousbrainbasal nucleicaudate nucleus  
     brainbasal nucleicorpus callosum  
     braindiencephalonamygdala  
    Reproductivefemale systemovary  predominantly
    Respiratoryrespiratory tractlarynx  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminus containing an activation domain, which is necessary and sufficient for synergistic activation of LEF1-mediated transcription by CALCOCO1 and beta-catenin, and EP300 binding motif, which is important for synergistic cooperation with EP300 as coactivators for LEF1 and beta-catenin
  • a rodlike tail sequence highly repetitive, composed of an heptapeptide repeat pattern characteristic of alpha-helical coiled coils
  • C-terminal activation domain (AD) is used for downstream signaling, possesses strong transactivation activity and is required for the coactivator function of CALCOCO1 with nuclear receptor
  • HOMOLOGY
    interspecies ortholog to rattus KIAA1536
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • activating inorganic pyrophosphatase (IPP) and enhancing phosphoglucomutase activity through the activated IPP
  • required for protein transport from the er to the golgi complex
  • involved in transcriptional activation of target genes by nuclear receptors and the xenobiotic aryl hydrocarbon receptor, as well as target genes of the Wnt signaling pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • phosphorylated by MAPK1
  • EP300 is a functionally important interaction partner of CALCOCO1 activation domain and their interaction potentiates transcriptional activation by the p160 coactivator complex
  • ARNT interact with two coiled coil coactivators, TRIP11 and CALCOCO1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS