protein
| is a novel negative regulator of TLR signaling and reveals its capacity to target MHC Class III genes at the molecular and functional level  |
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TRIM39 stabilizes CACTIN protein and CACTIN is upregulated after TNF stimulation  |
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CACTIN is essential for efficient splicing of thousands of pre-mRNAs, and incomplete splicing of the pre-mRNA of sororin (also known as CDCA5), a cohesin-associated factor, is largely responsible for the aberrant chromatid separation in cactin-depleted cells  |
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CACTIN physically and functionally interacts with the spliceosome-associated factors DHX8 and SRRM2  |
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SDE2 facilitates spliceosomal association of CACTIN/Cay1, with a functional link between SDE2 and CACTIN further supported by genetic interactions and pre-mRNA splicing assays  |