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FLASH GENE
Symbol CACTIN contributors: mct - updated : 02-11-2020
HGNC name cactin, spliceosome C complex subunit
HGNC id 29938
Location 19p13.3      Physical location : -
Synonym name
  • chromosome 19 open reading frame 29
  • functional spliceosome-associated protein c
  • renal carcinoma antigen NY-REN-24
    • Synonym symbol(s) NY-REN-24, C19orf29, fSAPc, FLJ17482, FLJ59622
    DNA
    TYPE functioning gene
    STRUCTURE 16.17 kb     10 Exon(s)
    MAPPING cloned N linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2689 - 758 - 2016 26363554
    10 - 3583 - 758 - 2016 26363554
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestiveintestinesmall intestine  predominantly
    Lymphoid/Immunelymph node   moderately
    Reproductivefemale systemuteruscervix moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • required for fundamental processes such as cell proliferation, genome stability maintenance, organismal development and immune response
  • cellular complexes comprising CACTIN, DHX8 and SRRM2 sustain precise chromosome segregation, genome stability and cell proliferation by allowing faithful splicing of specific pre-mRNAs
  • FAM32A, CACTIN, SDE2, and NKAP-factors implicated in alternative splicing-further stabilize the catalytic conformation of the spliceosome during exon ligation, and these four proteins act as exon ligation factors
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a novel negative regulator of TLR signaling and reveals its capacity to target MHC Class III genes at the molecular and functional level
  • TRIM39 stabilizes CACTIN protein and CACTIN is upregulated after TNF stimulation
  • CACTIN is essential for efficient splicing of thousands of pre-mRNAs, and incomplete splicing of the pre-mRNA of sororin (also known as CDCA5), a cohesin-associated factor, is largely responsible for the aberrant chromatid separation in cactin-depleted cells
  • CACTIN physically and functionally interacts with the spliceosome-associated factors DHX8 and SRRM2
  • SDE2 facilitates spliceosomal association of CACTIN/Cay1, with a functional link between SDE2 and CACTIN further supported by genetic interactions and pre-mRNA splicing assays
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS