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FLASH GENE
Symbol CACNG8 contributors: mct - updated : 26-03-2008
HGNC name calcium channel, voltage-dependent, gamma subunit 8
HGNC id 13628
Location 19q13.4      Physical location : 54.466.293 - 54.486.139
Synonym name neuronal voltage-gated calcium channel gamma-8 subunit
Synonym symbol(s) CCG8
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 19.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - PRKCG - CACNG7 - CACNG8 - CACNG6 - qter
Authors Burgess (01)
Physical map
ZNF331 19q13.3-q13.4 zinc finger protein 331 LOC284379 19q13.42 similar to solute carrier family 7, member 3; amino acid transporter, cationic 3; solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 LOC390970 19 similar to DC2 protein NALP12 19q13.42 NACHT, leucine rich repeat and PYD containing 12 LOC91663 PRKCG 19q13.4 protein kinase C, gamma CACNG7 19q13.4 calcium channel, voltage-dependent, gamma subunit 7 CACNG8 19q13.4 calcium channel, voltage-dependent, gamma subunit 8 CACNG6 19q13.4 calcium channel, voltage-dependent, gamma subunit 6 UNQ3033 19q13.42 LAIR hlog OSCAR 19q13.42 osteoclast-associated receptor NDUFA3 19q13.42 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa TFPT 19q13.4 TCF3 (E2A) fusion partner (in childhood Leukemia) PRPF31 19q13.42 PRP31 pre-mRNA processing factor 31 homolog (yeast) CNOT3 19q13.4 CCR4-NOT transcription complex, subunit 3 LENG1 19q13.4 leukocyte receptor cluster (LRC) member 1 TMC4 19q13.42 transmembrane channel-like 4 LENG4 19q13.4 transmembrane channel-like 4 LENG5 19q13.4 leukocyte receptor cluster (LRC) member 5 RPS9 19q13.4 ribosomal protein S9 LILRB3 19q13.4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 ILT8 19q13.4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 6 LILRB5 19q13.4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5 LILRB2 19q13.4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 LOC390971 19 similar to YME1-like 1; ATP-dependent metalloprotease FtsH1 LILRA3 19q13.4 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1417 - 425 - Chu (2001)
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainlimbic systemhippocampus  
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Cacng8
Homologene
FAMILY PMP22/EMP/MP20 family, CACNG subfamily
CATEGORY transport channel
SUBCELLULAR LOCALIZATION     plasma membrane
text distributed both in synaptic and extra-synaptic plasma membranes of the hippocampal neuron
basic FUNCTION
  • stabilizing the calcium channel in an inactive (closed) state
  • initiate translation from a non-AUG (CUG) start codon
  • have distinct roles in postsynaptic membranes under the regulation of different intracellular signaling pathways
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS