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FLASH GENE
Symbol CACNG1 contributors: mlc - updated : 30-11-2007
HGNC name calcium channel, voltage-dependent, gamma subunit 1
HGNC id 1405
Location 17q24      Physical location : 65.040.705 - 65.052.909
Synonym name
  • dihydropyridine-sensitive L-type skeletal muscle calcium channel gamma subunit
  • neuronal dihydropyridine-sensitive calcium channel gamma subunit
  • Synonym symbol(s) CACNLG, DHPRG
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text in a cluster with two similar gamma subunit-encoding genes
    STRUCTURE 12.00 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1266 - 222 - Chu (2001)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    Muscularstriatumcardiac  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY PMP-22/EMP/MP20 family, CACNG subfamily
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • subunit of the dihydropyridine (dhp) sensitive calcium channel, playing a role in excitation-contraction coupling
  • functions as an endogenous Ca2+ antagonist whose task may be to minimize Ca2+ entry and Ca2+ release under stress-induced conditions favoring plasmalemma depolarization
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS