basic FUNCTION
| calcium voltage-gated channel (VDCC), R type, involved in the modulation of calcium mediated hormone secretion, forming pores |
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share dual roles during neurotransmitter release |
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having a role for second-phase insulin secretion |
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CACNA1E E/R-type Ca2+ channels are important in modulating thalamocortical hyperoscillation exerting anti-epileptogenic effects in non-convulsive absence seizures |
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CACNA1E channels are critical for oscillatory burst discharges in reticular thalamus (RT) neurons and for the expression of absence epilepsy |
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does not only contribute to the cardiac autonomous nervous system but also to intrinsic rhythm propagation |
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conducts high-voltage-activated, rapidly inactivating R-type calcium currents, which are used to initiate rapid synaptic transmission |
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had a disproportionately increased contribution to synaptic transmission at frequencies >1 Hz |
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raft-dependent modulation of CACNA1E could be important in the physiological and pathophysiological processes in which these channels participate, including neuronal excitability, synaptic plasticity, epilepsy, and chronic pain |