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FLASH GENE
Symbol CABP7 contributors: mct/npt - updated : 11-03-2019
HGNC name calcium binding protein 7
HGNC id 20834
Location 22q12.2      Physical location : 30.116.343 - 30.127.818
Synonym name calneuron II
Synonym symbol(s) MGC57793, CALN2
DNA
TYPE functioning gene
SPECIAL FEATURE antisens
text antisense to LOC55954 over 1531 bp
STRUCTURE 11.48 kb     5 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 3001 24.3 215 - 2015 25717182
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal domain (NTD) but not the C-terminal domain (CTD) of CABP7 is able to interact independently with PI4KB
  • three EF-hand calcium-binding domains
  • C-terminal TMD in residues 189–205, necessary and sufficient for targeting to specific sub-cellular membrane domains (Mc Cue 2009)
    • mono polymer dimer
    HOMOLOGY
    interspecies homolog to murine Cabp7
    Homologene
    FAMILY
  • calmodulin and related proteins family
  • EF-hand superfamily
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytoskeleton
    intracellular,nuclear envelope
    text
  • cytoplasmic and cytoskeletal compartment of cell somata and dendrites
  • exhibit a membrane distribution distinct from the other CaBPs and consistent with localisation to the trans-Golgi network (TGN) (Mc Cue 2009)
  • exhibiting localisation predominantly to a peri-nuclear compartment, intracellular vesicles and in some instances the plasma membrane (Mc Cue 2009)
    • basic FUNCTION
  • possess a targeting mechanism that is unique amongst the CaBPs that may contribute to differential functional Ca2+-sensing by these family members (Mc Cue 2009)
  • important regulator of a variety of plasma membrane and intracellular cation channels in neuronal cell types principally modulating cytosolic Ca2+ concentrations through control of influx from the extracellular fluid or efflux from intracellular stores (Mc Cue 2009)
  • unique role for CABP7 and CALN1 in the regulation of PI4KB
  • CABP7 and CALN1 are transmembrane Calmodulin-like EF-hand Ca(2+)-sensors, and a function in the control of Golgi-to-plasma membrane vesicle trafficking has been assigned to both proteins
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • CABP7 forms soluble dimers in a Ca2+-independent manner
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
  • CALN1 and CABP7 physically associate with PI4KB, inhibit the enzyme profoundly at resting and low calcium levels, and negatively interfere with Golgi-to-plasma membrane trafficking
  • CALN1 and CABP7 are nonclassical type II tail-anchored proteins that are post-translationally inserted into the endoplasmic reticulum membrane via an association of a 23AA-long transmembrane domain (TMD) with the ASNA1 chaperone complex
  • CABP7 regulates lysosome clustering and PI4KB is essential for normal cytokinesis
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS