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FLASH GENE
Symbol CABIN1 contributors: mct/npt/pgu - updated : 09-06-2010
HGNC name calcineurin binding protein 1
HGNC id 24187
Location 22q11.23      Physical location : 24.407.764 - 24.574.596
Synonym name
  • similar to C. auratus neuropeptide Y
  • calcineurin inhibitor
  • Synonym symbol(s) KIAA0330, CAIN, PPP3IN
    DNA
    TYPE functioning gene
    STRUCTURE 166.83 kb     37 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    FBXW3 22q11 F-box and WD-40 domain protein 3 LOC343851 22q11.23 similar to hypothetical protein FLJ31547 FLJ31568 22q11.23 hypothetical protein FLJ31568 LOC388882 22 hypothetical gene supported by BC036910 LOC388883 22 similar to Gag-Pro-Pol protein IGLL1 22q11.22 immunoglobulin lambda-like polypeptide 1 LOC391321 22 similar to Rhabdoid tumor deletion region protein 1 LOC51233 22q11.2 hypothetical protein LOC51233 LOC388884 22 similar to Immunoglobulin lambda-like polypeptide 1 precursor (Immunoglobulin-related 14.1 protein) (Immunoglobulin omega polypeptide) (Lambda 5) (CD179b antigen) ASLL 22q11.22 argininosuccinate lyase-like Rgr 22q11.23 Ral-GDS related protein Rgr ZNF70 22q11.22 zinc finger protein 70 (Cos17) VPREB3 22q11.2 pre-B lymphocyte gene 3 FLJ36561 22q11.23 hypothetical protein FLJ36561 MMP11 22q11.22 matrix metalloproteinase 11 (stromelysin 3) SMARCB1 22q11.23 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 FLJ43842 22q11.23 FLJ43842 protein SLC2A11 22q11.2 solute carrier family 2 (facilitated glucose transporter), member 11 MIF 22q11.22 macrophage migration inhibitory factor (glycosylation-inhibiting factor) LOC284890 22q11.23 similar to lymphocyte activation-associated protein; kelch (Drosophila)-like 5 DDT 22q11.23 D-dopachrome tautomerase GSTT2 22q11.23 glutathione S-transferase theta 2 HS322B1A 22q12 hypothetical protein HS322B1A LOC391322 22 similar to D-dopachrome tautomerase (Phenylpyruvate tautomerase II) GSTT1 22q11.23 glutathione S-transferase theta 1 LOC343854 22q11.23 similar to RIKEN cDNA 4930583C14 CABIN1 22q11.2-q12.3 similar to RIKEN cDNA 4930583C14 BK65A6.2 GGTLA1 22q11.2 gamma-glutamyltransferase-like activity 1 LOC339661 22q11.23 similar to Gamma-glutamyltransferase-like protein 4 DKFZP434P211 22q11.22 POM121-like protein LOC388885 22 LOC388885 KIAA0376 22q11.2-q12.3 LOC388885 ADORA2A 22q11.22 adenosine A2a receptor UPB1 22q11.2 ureidopropionase, beta MGC1842 22q11.2 hypothetical protein MGC1842 SNRPD3 22q11.21 small nuclear ribonucleoprotein D3 polypeptide 18kDa GGT1 22q11.23 gamma-glutamyltransferase 1 LOC388886 22 similar to hypothetical protein LOC192734 LOC343855 22q11.23 similar to POM121 membrane glycoprotein-like 1 LOC391323 22 similar to actin-related protein 2 LOC388887 22 LOC388887 BCRL6 22q11.22 breakpoint cluster region-like 6 TOP1P2 22q11.2-q13.1 topoisomerase (DNA) I pseudogene 2 KIAA1941 22q11.23 KIAA1941 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    37 - 7222 246 2220 - 2007 17172641
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Lymphoid/Immunespleen    
    Nervousnervecranial nerve  highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a leucine zipper
  • a putative SH3 binding site
  • three putative nuclear localization signals (NLS)
  • several PEST sequences and phosphorylation sites
  • additional calcineurin CN) binding domain in its 701-900 amino acid residues
  • C-terminal CN binding region
  • HOMOLOGY
    interspecies homolog to murine procollagen alpha
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • transcriptional corepressor recruited by MEF2
  • binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction
  • recruiting chromatin-modifying enzymes, both histone deacetylases and a histone methyltransferase, to repress MEF2 transcriptional activity
  • recruited to promoters through its interactions with DNA sequence-specific-binding protein MEF2
  • implicated in regulation of neurotransmitter endocytosis in neuronal cells and muscle cell development
  • recruiting SUV39H1 and repressing transcriptional activity
  • inhibits TP53 function on chromatin in the quiescent state
  • is a functional member of the human HUCA complex
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    text apoptosis of T cells
    PATHWAY
    metabolism
    signaling signal transduction
    a component part of the quaternary HIRA/UBN1/CABIN1/ASF1A (HUCA) complex, assembled from recombinant proteins
    INTERACTION
    DNA binding on the MEF2 target promoter in a calcium-dependent manner
    RNA
    small molecule
    protein
  • binding to calmodulin which releases its association to MEF2, releasing of MEF2 and/or CABIN1, in a mutually exclusive manner
  • interaction with a histone methyltransferase
  • binding to SUV39H1
  • bind directly to calcineurin (CN) using its C-terminal region and inhibit CN activity
  • association with intracellular domains involved in GRM protein coupling provides an additional mechanism by which GRM5 endocytosis and signaling are regulated
  • interacted with HIRA and their interaction domain was mapped to the C-terminal half of HIRA and the N-terminal part of CABIN1, and opposes MEF2- and HIRA-dependent transcription as assumed by its ability to tether repressive chromatin remodelers
  • HIRA and CABIN1 interact at ectopic and endogenous levels of expression in cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS