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Symbol CABIN1 contributors: mct/npt/pgu - updated : 09-06-2010
HGNC name calcineurin binding protein 1
HGNC id 24187
Location 22q11.23      Physical location : 24.407.764 - 24.574.596
Synonym name
  • similar to C. auratus neuropeptide Y
  • calcineurin inhibitor
  • Synonym symbol(s) KIAA0330, CAIN, PPP3IN
    TYPE functioning gene
    STRUCTURE 166.83 kb     37 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    FBXW3 22q11 F-box and WD-40 domain protein 3 LOC343851 22q11.23 similar to hypothetical protein FLJ31547 FLJ31568 22q11.23 hypothetical protein FLJ31568 LOC388882 22 hypothetical gene supported by BC036910 LOC388883 22 similar to Gag-Pro-Pol protein IGLL1 22q11.22 immunoglobulin lambda-like polypeptide 1 LOC391321 22 similar to Rhabdoid tumor deletion region protein 1 LOC51233 22q11.2 hypothetical protein LOC51233 LOC388884 22 similar to Immunoglobulin lambda-like polypeptide 1 precursor (Immunoglobulin-related 14.1 protein) (Immunoglobulin omega polypeptide) (Lambda 5) (CD179b antigen) ASLL 22q11.22 argininosuccinate lyase-like Rgr 22q11.23 Ral-GDS related protein Rgr ZNF70 22q11.22 zinc finger protein 70 (Cos17) VPREB3 22q11.2 pre-B lymphocyte gene 3 FLJ36561 22q11.23 hypothetical protein FLJ36561 MMP11 22q11.22 matrix metalloproteinase 11 (stromelysin 3) SMARCB1 22q11.23 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 FLJ43842 22q11.23 FLJ43842 protein SLC2A11 22q11.2 solute carrier family 2 (facilitated glucose transporter), member 11 MIF 22q11.22 macrophage migration inhibitory factor (glycosylation-inhibiting factor) LOC284890 22q11.23 similar to lymphocyte activation-associated protein; kelch (Drosophila)-like 5 DDT 22q11.23 D-dopachrome tautomerase GSTT2 22q11.23 glutathione S-transferase theta 2 HS322B1A 22q12 hypothetical protein HS322B1A LOC391322 22 similar to D-dopachrome tautomerase (Phenylpyruvate tautomerase II) GSTT1 22q11.23 glutathione S-transferase theta 1 LOC343854 22q11.23 similar to RIKEN cDNA 4930583C14 CABIN1 22q11.2-q12.3 similar to RIKEN cDNA 4930583C14 BK65A6.2 GGTLA1 22q11.2 gamma-glutamyltransferase-like activity 1 LOC339661 22q11.23 similar to Gamma-glutamyltransferase-like protein 4 DKFZP434P211 22q11.22 POM121-like protein LOC388885 22 LOC388885 KIAA0376 22q11.2-q12.3 LOC388885 ADORA2A 22q11.22 adenosine A2a receptor UPB1 22q11.2 ureidopropionase, beta MGC1842 22q11.2 hypothetical protein MGC1842 SNRPD3 22q11.21 small nuclear ribonucleoprotein D3 polypeptide 18kDa GGT1 22q11.23 gamma-glutamyltransferase 1 LOC388886 22 similar to hypothetical protein LOC192734 LOC343855 22q11.23 similar to POM121 membrane glycoprotein-like 1 LOC391323 22 similar to actin-related protein 2 LOC388887 22 LOC388887 BCRL6 22q11.22 breakpoint cluster region-like 6 TOP1P2 22q11.2-q13.1 topoisomerase (DNA) I pseudogene 2 KIAA1941 22q11.23 KIAA1941 protein
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    37 - 7222 246 2220 - 2007 17172641
    Type ubiquitous
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Nervousnervecranial nerve  highly
    Visualeye   highly
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    at STAGE
  • a leucine zipper
  • a putative SH3 binding site
  • three putative nuclear localization signals (NLS)
  • several PEST sequences and phosphorylation sites
  • additional calcineurin CN) binding domain in its 701-900 amino acid residues
  • C-terminal CN binding region
    interspecies homolog to murine procollagen alpha
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • transcriptional corepressor recruited by MEF2
  • binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction
  • recruiting chromatin-modifying enzymes, both histone deacetylases and a histone methyltransferase, to repress MEF2 transcriptional activity
  • recruited to promoters through its interactions with DNA sequence-specific-binding protein MEF2
  • implicated in regulation of neurotransmitter endocytosis in neuronal cells and muscle cell development
  • recruiting SUV39H1 and repressing transcriptional activity
  • inhibits TP53 function on chromatin in the quiescent state
  • is a functional member of the human HUCA complex
  • CELLULAR PROCESS cell life, cell death/apoptosis
    text apoptosis of T cells
    signaling signal transduction
    a component part of the quaternary HIRA/UBN1/CABIN1/ASF1A (HUCA) complex, assembled from recombinant proteins
    DNA binding on the MEF2 target promoter in a calcium-dependent manner
    small molecule
  • binding to calmodulin which releases its association to MEF2, releasing of MEF2 and/or CABIN1, in a mutually exclusive manner
  • interaction with a histone methyltransferase
  • binding to SUV39H1
  • bind directly to calcineurin (CN) using its C-terminal region and inhibit CN activity
  • association with intracellular domains involved in GRM protein coupling provides an additional mechanism by which GRM5 endocytosis and signaling are regulated
  • interacted with HIRA and their interaction domain was mapped to the C-terminal half of HIRA and the N-terminal part of CABIN1, and opposes MEF2- and HIRA-dependent transcription as assumed by its ability to tether repressive chromatin remodelers
  • HIRA and CABIN1 interact at ectopic and endogenous levels of expression in cells
  • cell & other